Phytochemical interventions for post-traumatic stress disorder:A cluster co-occurrence network analysis using CiteSpace  

作　　者：Biao Gao Yi-cui Qu Meng-yu Cai Yin-yin Zhang Hong-tao Lu Hong-xia Li Yu-xiao Tang Hui Shen 

机构地区：[1]Department of Naval Nutrition and Food Hygiene,Naval Medical University,Shanghai 200433,China [2]Teaching and Research Support Center,Naval Medical University,Shanghai 200433,China

出　　处：《Journal of Integrative Medicine》2023年第4期385-396,共12页结合医学学报（英文版）

基　　金：the National Natural Science Foundation of China(No.81573150);Military Key Discipline Construction Projects of China(No.HL21JD1206).

摘　　要：Objective:This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder(PTSD).Methods:The Web of Science database(2007-2022)was searched using the search terms“phytochemicals”and“PTSD,”and relevant literature was compiled.Network clustering co-occurrence analysis and qualitative narrative review were conducted.Results:Three hundred and one articles were included in the analysis of published research,which has surged since 2015 with nearly half of all relevant articles coming from North America.The category is dominated by neuroscience and neurology,with two journals,Addictive Behaviors and Drug and Alcohol Dependence,publishing the greatest number of papers on these topics.Most studies focused on psychedelic intervention for PTSD.Three timelines show an“ebb and flow”phenomenon between“substance use/marijuana abuse”and“psychedelic medicine/medicinal cannabis.”Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover,serotonin levels,and brain-derived neurotrophic factor expression.Conclusion:Research on phytochemicals and PTSD is unevenly distributed across countries/regions,disciplines,and journals.Since 2015,the research paradigm shifted to constitute the mainstream of psychedelic research thus far,leading to the exploration of botanical active ingredients and molecular mechanisms.Other studies focus on anti-oxidative stress and anti-inflammation.

关 键 词：PHYTOCHEMICAL Post-traumatic stress disorder Text analysis Clustering co-occurrence network PSYCHEDELIC 

分 类 号：R749.5[医药卫生—神经病学与精神病学]