Identification of retinal thickness and blood flow in agerelated macular degeneration with reticular pseudodrusen  

作　　者：Yong-Zhao Wei Hao Huang Xiang Zhang Hong-Hua Yu Bao-Yi Liu Yu-Yao Diao Lu Cheng Hao Cheng 

机构地区：[1]Department of Ophthalmology,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,Guangdong Province,China [2]State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510275,Guangdong Province,China [3]Guangdong Eye Institute,Department of Ophthalmology,Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,Guangdong Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第8期1268-1273,共6页国际眼科杂志（英文版）

基　　金：Supported by the“Municipal School(College)Joint Funding(Zhongnanshan Medical Foundation of Guangdong Province)Project”of Guangzhou Municipal Science and Technology Bureau(No.202201020458).

摘　　要：AIM:To investigate thickness characteristics and vascular plexuses in retinas with reticular pseudodrusen(RPD)as an early detection strategy for age-related macular degeneration(AMD).METHODS:This retrospective study included 24 subjects(33 eyes)with RPD and 25 heathy control subjects(34 eyes).The superficial capillary plexus(SCP)and the deep capillary plexus(DCP)of the retinal posterior poles were investigated with optical coherence tomography angiography(OCTA).Retinal thicknesses and vessel densities were analyzed statistically.RESULTS:The general retinal thicknesses of RPD eyes were significantly decreased(95%CI-14.080,-0.655;P=0.032).The vessel densities of DCP in RPD eyes were significantly increased in the global(95%CI 1.067,7.312;P=0.027),parafoveal(95%CI 0.417,5.241;P=0.022),and perifoveal(95%CI 0.181,6.842;P=0.039)quadrants.However,the vessel densities of the SCP were rarely increased in the eyes with RPD.CONCLUSION:The thinning of retinas in the RPD group suggests a reduction in the number of cells.Additionally,the increased vessel density of the DCP in retinas with RPD indicates a greater demand for blood supply,possibly due to the hypoxia induced RPD compensation caused by RPD in the outer retina.This study highlights the pathological risks associated with RPD and emphasizes the importance of early intervention to retard the progression of AMD.

关 键 词：reticular pseudodrusen age-related macular degeneration retinal thickness retinal vessel density optical coherence tomography angiography 

分 类 号：R774.5[医药卫生—眼科]