舒肝健胃丸联合埃索美拉唑镁肠溶片和莫沙必利片治疗胃食管反流病的效果对比  

Comparison of the effect of Shugan Jianwei pills combined with esomeprazole magnesium enteric-coated tablets and mosapride tablets in the treatment of gastroesophageal reflux disease

作　　者：黄鹤[1] HUANG He(Air Force Hospital of Northern Theater of PLA,Shenyang 110042,China)

机构地区：[1]中国人民解放军北部战区空军医院,110042

出　　处：《中国现代药物应用》2023年第14期141-143,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探索舒肝健胃丸联合埃索美拉唑镁肠溶片、莫沙必利片治疗胃食管反流病患者的效果。方法87例胃食管反流病患者,随机分为对照组(43例)及实验组(44例)。对照组患者服用埃索美拉唑镁肠溶片联合莫沙必利片治疗,实验组患者在对照组基础上结合舒肝健胃丸治疗。比较两组患者治疗前后的反流性疾病问卷(RDQ)评分及食管24 h pH检测指标(反流持续≥5 min次数、最长反流持续时间、pH<4的总时间百分比、DeMeester评分)。结果治疗后,实验组患者的反酸、反流、烧心、非心源性胸痛评分及RDQ总分分别为(3.83±1.49)、(3.17±1.28)、(2.97±1.14)、(2.69±1.24)、(12.21±3.59)分,均低于对照组的(4.55±1.24)、(4.06±1.62)、(3.61±1.38)、(3.03±1.35)、(14.89±4.19)分,差异具有统计学意义(P<0.05)。治疗后,实验组患者的反流持续≥5 min次数(2.96±2.34)次少于对照组的(3.85±1.23)次,最长反流持续时间(7.93±2.44)min短于对照组的(11.43±3.20)min,pH<4的总时间百分比(6.02±3.25)%及DeMeester评分(8.07±3.06)分低于对照组的(7.55±3.40)%、(10.48±2.68)分,差异具有统计学意义(P<0.05)。结论采用舒肝健胃丸联合埃索美拉唑镁肠溶片、莫沙必利片治疗胃食管反流病的效果确切。Objective To investigate the effect of Shugan Jianwei pills combined with esomeprazole magnesium enteric-coated tablets and mosapride tablets in the treatment of gastroesophageal reflux disease.Methods A total of 87 patients with gastroesophageal reflux disease were randomly divided into control group(43 cases)and experimental group(44 cases).The control group was treated with esomeprazole magnesium enteric-coated tablets and mosapride tablets,and the experimental group was treated with Shugan Wei'an granules on the basis of the control group.Both groups were compared in terms of reflex disease questionnaire(RDQ)score,24 h esophageal pH markers(number of reflux lasting≥5 min,longest duration of reflux,percentage of total time with pH<4,DeMeester score)before and after treatment.Results After treatment,the scores of acid reflux,regurgitation,heartburn,non-cardiogenic chest pain and total RDQ score were(3.83±1.49),(3.17±1.28),(2.97±1.14),(2.69±1.24)and(12.21±3.59)points in the experimental group,which were lower than those of(4.55±1.24),(4.06±1.62),(3.61±1.38),(3.03±1.35)and(14.89±4.19)points in the control group,and the differences were statistically significant(P<0.05).After treatment,the number of reflux lasting≥5 min was(2.96±2.34)times in the experimental group,which was less than that of(3.85±1.23)times in the control group;the longest duration of reflux of(7.93±2.44)min in the experimental group was shorter than that of(11.43±3.20)min in the control group;the percentage of total time with pH<4 of(6.02±3.25)%and DeMeester score of(8.07±3.06)points in the experimental group were lower than those of(7.55±3.40)%and(10.48±2.68)points in the control group;the differences were statistically significant(P<0.05).Conclusion Shugan Jianwei pills combined with esomeprazole magnesium enteric-coated tablets and mosapride tablets is effective in the treatment of gastroesophageal reflux disease.

关 键 词：舒肝健胃丸 埃索美拉唑镁肠溶片 莫沙必利片 胃食管反流病 PH 

分 类 号：R571[医药卫生—消化系统]