CD40/CD40L与缺血性脑卒中的关系  

Relationship between CD40/CD40L and ischemic stroke

作　　者：田祺(综述) 郝春艳[2] 段虎斌(审校)[3] TIAN Qi;HAO Chun-yan;DUAN Hu-bin(Department of Neurosurgery,Lvliang Hospital Affiliated to Shanxi Medical University,Lvliang 033000,Shanxi,CHINA;The First Clinical Medical School of Shanxi Medical University,Taiyuan 030001,Shanxi,CHINA;Department of Neurosurgery,the First Clinical Medical School of Shanxi Medical University,Taiyuan 030001,Shanxi,CHINA)

机构地区：[1]山西医科大学附属吕梁医院神经外科,山西吕梁033000 [2]山西医科大学第一临床医学院,山西太原030001 [3]山西医科大学第一医院神经外科,山西太原030001

出　　处：《海南医学》2023年第15期2269-2272,共4页Hainan Medical Journal

基　　金：山西省回国留学人员科研资助项目(编号:2011-096);山西医科大学第一医院项目资助(编号:晋留管办发[2011]8号);山西省自然科学基金面上自然基金项目(编号:201601D011119);山西医科大学第一医院项目资助(编号:晋财教[2016]103号);山西省自然探索类自然科学研究面上项目(编号:20210302123247);山西医科大学第一医院项目资助(编号:晋政办发[2016]76号)。

摘　　要：缺血性脑卒中是危害人类健康的主要疾病,其主要的危险因素是不稳定斑块的脱落。CD40和CD40受体(CD40L)是由白细胞分化的,在动脉粥样硬化患者中高表达,它们的相互作用导致动脉粥样硬化斑块的不稳定,从而诱发斑块脱落,导致缺血性脑卒中。因此,探讨CD40/CD40L在缺血性脑卒中的调控机制,了解缺血性脑卒中的病理生理,对阻止动脉粥样硬化的形成、预防缺血性脑卒中有重要意义。Ischemic stroke is a major disease that endangers human health,and its main risk factor is the shedding of unstable plaques.CD40 and CD40 receptor(CD40L)is differentiated by leukocytes and is highly expressed in patients with atherosclerosis.Their interaction leads to the instability of atherosclerotic plaques,which induces plaque shedding and leads to ischemic stroke.Therefore,it is of great significance to explore the regulatory mechanism of CD40/CD40L in ischemic stroke and understand the pathophysiology of ischemic stroke to prevent the formation of atherosclerosis and ischemic stroke.

关 键 词：缺血性脑卒中 动脉粥样硬化 CD40 CD40受体 可溶性的CD40受体 

分 类 号：R743.3[医药卫生—神经病学与精神病学]