SREBP1在乙肝病毒感染相关性肝细胞癌中表达意义的探讨  

The significance of SREBP1 expression in HBV-related hepatocellular carcinoma

作　　者：邓慧孜 郑晶[1] 翁阳[1] 魏尚 DENG Hui-zi;ZHENG Jing;WENG Yang;WEI Shang(Department of Pathology,the First Affiliated Hospital of Hainan Medical University,Haikou 570100)

机构地区：[1]海南医学院第一附属医院病理科,海南海口570100

出　　处：《海南医学院学报》2023年第15期1151-1155,1161,共6页Journal of Hainan Medical University

基　　金：海南省自然科学基金项目(820RC763)。

摘　　要：目的:探讨SREBP1蛋白表达与乙肝病毒感染相关性肝细胞癌临床病理特征的关系。方法:收集91例海南医学院第一附属医院病理科乙肝病毒感染相关性肝细胞癌及配对癌旁肝组织样本,制作成组织芯片,通过免疫组织化学染色方法检测SREBP1蛋白在癌及配对癌旁组织中的表达情况,通过卡方检验分析SREBP1蛋白表达与肝细胞癌临床病理特征的关系。结果:免疫组织化学染色方法检测结果显示,SREBP1蛋白在肝细胞癌中的表达显著高于配对癌旁肝组织(P<0.001);SREBP1蛋白的表达水平与肝细胞癌患者的肿瘤分化、远处转移或局部复发均显著相关(P<0.05);与乙肝病毒感染相关性肝细胞癌病毒低载量组(0~10^(3)IU/mL)相比,SREBP1蛋白在乙肝病毒感染相关性肝细胞癌病毒高载量组(>10^(3)IU/mL)中表达明显上调(P<0.05)。结论:(1)SREBP1蛋白的表达与肝细胞癌存在相关性,且呈现高表达趋势,为后续肝细胞癌发生、发展相关的脂质代谢调节机制研究提供方向及理论依据;(2)SREBP1蛋白表达与乙肝病毒复制活性存在相关性,为乙肝病毒感染相关性肝癌发生、发展相关机制探究提供新的研究方向。Objective:To investigate the relationship between SREBP1 protein expression and clinicopathological features of hepatitis B virus infection-related hepatocellular carcinoma.Methods:A total of 91 cases of hepatocellular carcinoma associated with hepatitis B virus infection and paired adjacent liver tissue samples were collected from the Department of Pathology,the First Affiliated Hospital of Hainan Medical College.The expression of SREBP1 protein in cancer and paired adjacent tissues was detect-ed by immunohistochemical staining.The relationship between SREBP1 protein expression and clinicopathological features of he-patocellular carcinoma was analyzed by chi-square test.Results:The results of immunohistochemical staining showed that the ex-pression of SREBP1 protein in hepatocellular carcinoma was significantly higher than that in adjacent liver tissues(P<0.001).The expression level of SREBP1 protein was significantly correlated with tumor differentiation,distant metastasis or local recur-rence in patients with hepatocellular carcinoma(P<0.05).The expression of SREBP1 protein was significantly up-regulated in the high HBV-related HCC virus load group(>10^(3)IU/mL)compared with the low HBV-related HCC virus load group(0~10^(3)IU/mL)(P<0.05).Conclusion:1.The expression of SREBP1 protein is correlated with hepatocellular carcinoma,and shows a high expression trend,which provides direction and theoretical basis for the study of lipid metabolism regulation mecha-nism related to the occurrence and development of hepatocellular carcinoma.2.The expression of SREBP1 protein is correlated with the replication activity of hepatitis B virus,which provides a new research direction for the exploration of the mechanism of the occurrence and development of hepatitis B virus infection-related liver cancer.

关 键 词：SREBP1 肝细胞癌 慢性乙型肝炎病毒 脂质从头合成 

分 类 号：R735.7[医药卫生—肿瘤]