基于网络药理学和分子对接技术研究竹节参抗炎作用的机制  

Study on Anti-inflammatory Effect Mechanism of Panax Japonicus Based on Network Pharmacology and Molecular Docking Technology

作　　者：李思齐 闫子欣 张宗泽 宋萍萍 孙璐宏 Li Si-qi;Yan Zi-xin;Zhang Zong-ze;Song Ping-ping;Sun Lu-hong(School of Life Science and Technology,Wuhan Polytechnic University,Wuhan 430023,Hubei Province,China;Wuhan Polytechnic University Library,Wuhan 430023,Hubei Province,China)

机构地区：[1]武汉轻工大学生命科学与技术学院,湖北武汉430023 [2]武汉轻工大学图书馆,湖北武汉430023

出　　处：《科学与信息化》2023年第15期164-168,共5页Technology and Information

摘　　要：利用TCMSP数据库获取竹节参的活性成分,GeneCards、OMIM和TTD数据库收集炎症相关靶点;采用Cytoscape、STRING等软件构建竹节参活性成分-靶点互作网络图;运用Autodock vina软件进行分子对接验证;利用David数据库进行GO、KEGG分析。筛选得到竹节参关键活性成分8个,核心靶点5个;分子对接验证结果表明关键活性成分与核心靶点结合稳定。富集到生物过程(BP)385条、分子功能(MF)96条、细胞组分(CC)47条;KEGG通路137条。初步揭示了竹节参是通过多成分、多靶点、多条信号通路协同发挥抗炎作用,旨在为深入研究提供理论依据。TCMSP database is used to obtain the active components of Panax japonicus,and GeneCards,OMIM and TTD databases are used to collect inflammation-related targets.Cytoscape,STRING and other software are used to construct the Panax japonicus active component-target interaction network diagram.Autodock vina software is used for molecular docking verification.David database is used for GO and KEGG analysis.Eight key active components of Panax japonicus and 5 core targets are screened.The molecular docking verification results show that,the key active components bind stably to the core targets.The enrichment analysis shows 385 biological process(BP)pathways,96 molecular function(MF)pathways,47 cellular component(CC)pathways;and 137 KEGG pathways.It is preliminarily revealed that Panax japonicus exerts antiinflammatory effects through multi-component,multi-target and multi-signaling pathways,aiming to provide a theoretical basis for in-depth research.

关 键 词：网络药理学 竹节参 抗炎 作用机制 分子对接 

分 类 号：R28[医药卫生—中药学]