蛛网膜下腔出血的脑损伤机制及相关生物标志物研究进展  

Research advances in the mechanism of brain injury and related biomarkers in spontaneous subarachnoid hemorrhage

作　　者：刘胜[1] 李明昌[1] LIU Sheng;LI Mingchang(Department of Neurosurgery,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China)

机构地区：[1]武汉大学人民医院神经外科,湖北武汉430060

出　　处：《国际神经病学神经外科学杂志》2023年第3期51-59,共9页Journal of International Neurology and Neurosurgery

基　　金：国家自然科学基金资助项目(81971870,82172173)。

摘　　要：蛛网膜下腔出血(SAH)是一种严重的急性出血性脑卒中,具有极高的致死率和致残率。出血后发生脑损伤的机制主要包括早期脑损伤和迟发性脑缺血,最终会导致预后不良。目前,治疗并减轻脑损伤的措施有限。在此,笔者回顾了SAH动物模型及SAH后脑损伤的病理机制,并总结了相关的生物标志物在脑损伤及预后不良中的作用,以期为SAH的药物研发及临床治疗方案制订提供思路。Spontaneous subarachnoid hemorrhage(SAH) is a severe acute hemorrhagic stroke with extremely high mortality and disability rates.The main mechanisms of brain injury after hemorrhage include early brain injury and delayed cerebral ischemia,which will eventually lead to poor prognosis.At present,there are limited measures to treat and alleviate brain injury.This article reviews the animal model of SAH and the pathological mechanism of brain injury after SAH and summarizes the role of related biomarkers in brain injury and poor prognosis,in order to provide ideas for developing drugs and clinical treatment regimens for SAH.

关 键 词：蛛网膜下腔出血 动物模型 早期脑损伤 迟发性脑缺血 生物标志物 

分 类 号：R743[医药卫生—神经病学与精神病学]