同时多层采集技术结合分段读出平面回波成像序列弥散加权成像评估直肠腺癌病理分化程度  

Diffusion weighted imaging based on simultaneous multi-slice acquisition technique combined with readout-segmented echo-planar imaging sequence for evaluating degree of pathological differentiation of rectal adenocarcinoma

作　　者：罗明芳 周蜜 李方 何岳丰 黄红云[1] LUO Mingfang;ZHOU Mi;LI Fang;HE Yuefeng;HUANG Hongyun(Department of Radiology,Sichuan Academy of Medical Sciences,Sichuan Provincial People's Hospital,Chengdu 610072,China)

机构地区：[1]四川省医学科学院·四川省人民医院放射科,四川成都610072

出　　处：《中国介入影像与治疗学》2023年第8期483-487,共5页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的观察不同层加速因子同时多层(SMS)采集技术结合分段读出平面回波成像序列(rs-EPI)弥散加权成像(DWI)评估直肠腺癌病理分化程度的可行性。方法回顾性分析59例经术后病理证实的直肠腺癌患者,均接受直肠常规rs-EPI序列(DWI_(1))、层加速因子为2的SMS技术结合rs-EPI序列(DWI2)及层加速因子为3的SMS技术结合rs-EPI序列(DWI_(3))DWI检查,采集时间分别为137、60、51 s,获得相应表观弥散系数(ADC)。根据术后组织病理学所见将病灶分为高、中、低分化,比较不同分化程度直肠腺癌之间ADC,以及相同分化程度内ADC的差异,分析ADC与直肠腺癌分化程度的相关性。结果高、中分化与低分化直肠腺癌间ADC_(1)、ADC_(2)、ADC_(3)差异均有统计学意义(P均<0.05);高、中分化直肠腺癌间ADC差异均无统计学意义(P均>0.05)。高分化直肠腺癌ADC_(1)、ADC_(2)及ADC_(3)总体差异无统计学意义(P=0.08);中、低分化直肠腺癌ADC_(3)值均低于ADC_(1)及ADC_(2)(P均<0.01),ADC_(1)与ADC_(2)差异均无统计学意义(P均>0.05)。直肠腺癌病理分化程度与ADC_(1)(r_(s)=0.49,P<0.01)、ADC_(2)(r_(s)=0.51,P<0.01)及ADC_(3)(r_(s)=0.40,P<0.05)均呈正相关。结论以层加速因子为2的SMS技术结合rs-EPI采集的DWI可用于评估直肠腺癌病理分化程度。Objective To investigate the feasibility of diffusion weighted imaging(DWI)based on simultaneous multi-slice(SMS)acquisition technique with different layer acceleration factors combined with readout-segmented echo-planar imaging sequence(rs-EPI)for evaluating pathological differentiation degree of rectal adenocarcinoma.Methods Data of 59 patients with rectal adenocarcinoma confirmed by postoperative pathology were retrospectively analyzed.All patient underwent rectal conventional rs-EPI sequence(DWI_(1)),SMS of layer acceleration factor of 2 combined with rs-EPI sequence(DWI_(2)),as well as SMS of layer acceleration factor of 3 combined with rs-EPI sequence(DWI_(3))with acquisition time of 137 s,60 s and 51 s,respectively,and then corresponding apparent dispersion coefficient(ADC)were obtained.According to histopathological findings,the lesions were divided into high,medium and low differentiation.ADC of lesions with different differentiation degrees were compared,so were different ADC values of lesions with the same differentiation degree.The correlation of ADC and differentiation degrees of rectal adenocarcinoma were analyzed.Results Statistical differences of ADC_(1),ADC_(2) and ADC_(3) were found between high or medium differentiation and low differentiation rectal adenocarcinomas(all P<0.05),but not of ADC values between high and medium differentiation rectal adenocarcinoma(all P>0.05).No significant difference of ADC_(1),ADC_(2) and ADC_(3) was found in high differentiation rectal adenocarcinoma(P=0.08).ADC_(3) value of medium and low differentiation rectal adenocarcinoma were all lower than that of ADC_(1) and ADC_(2)(all P<0.01),but no significant differences between ADC_(1) and ADC_(2) were detected(both P>0.05).The pathological differentiation degrees of rectal adenocarcinoma were positively correlated with lesions ADC_(1)(r_(s)=0.49,P<0.01),ADC_(2)(r_(s)=0.51,P<0.01)and ADC_(3)(r s=0.40,P<0.05).Conclusion DWI based on SMS acquisition technology with acceleration factor of 2 combined with rs-EPI could b

关 键 词：直肠肿瘤 磁共振成像 弥散 分段读出平面回波成像 同时多层采集技术 病理分化 

分 类 号：R735.3[医药卫生—肿瘤] R445.2[医药卫生—临床医学]