肺部微生态与肺癌的关系研究进展  

Research progress on the relationship between lung microbiome and lung cancer

作　　者：葛怡俊 曹超[2] Ge Yijun;Cao Chao(Health Science Center,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学医学部,宁波315211 [2]宁波市第一医院呼吸与危重症科,宁波315010

出　　处：《新医学》2023年第8期540-544,共5页Journal of New Medicine

基　　金：宁波市科技计划项目科技创新2025重大专项(2019B10037)。

摘　　要：肺癌是全球癌症相关死亡的主要原因。肺部微生态是位于肺部的微生物群落。随着二代测序的飞速发展,人们发现微生物群落影响着宿主的营养、免疫、代谢和包括癌症在内的各种疾病的发生与发展。肺部微生态的失调带来持续的气道炎症和免疫反应,影响肺癌的发生、发展。深入探索肺癌患者肺部微生态特征,并将其应用于肺癌早期诊断、治疗及预后判断,有利于提高肺癌的临床疗效。该文就肺部微生态在肺癌中的相关研究进行阐述。Lung cancer is the leading cause of cancer-related deaths worldwide.Lung microbiome is defined as the microbial organisms located in the lung.With rapid development of next-generation sequencing,microbiome has been found to affect the host’s nutrition,immunity,metabolism and the occurrence or development of diseases including cancer.Dysbiosis of lung microbiome causes persistent airway inflammation and immune disorders,which affects the occurrence and development of lung cancer.In-depth exploration of lung microecological characteristics of lung cancer patients can be applied to early diagnosis,treatment and prognosis of lung cancer,which is beneficial to improve clinical efficacy of lung cancer.In this article,research progress on lung microbiome in lung cancer was reviewed.

关 键 词：肺部微生态 肺癌 微生物 免疫治疗 生物标志物 

分 类 号：R734.2[医药卫生—肿瘤]