64例胃神经内分泌肿瘤的分类、分级与临床特征及预后关系  

Study on the Relationship between Classification and Clinical Characteristics of 64 Cases of Gastric Neuroendocrine Tumor

作　　者：蒋蕾 邱静[1] 梁晓东[1] 王婷婷 JIANG Lei;Qiu Jing;LIANG Xiao-dong(Yancheng Third People's Hospital,Yancheng Jiangsu 224000)

机构地区：[1]盐城市第三人民医院,江苏盐城224000

出　　处：《医学临床研究》2023年第7期991-994,共4页Journal of Clinical Research

摘　　要：【目的】分析不同分类、分级胃神经内分泌肿瘤(G-NEN)患者的临床病理特征及预后。【方法】回顾性分析2016年6月至2022年1月盐城市第三人民医院收治的64例G-NEN患者,根据2019第五版WHO消化系统肿瘤分类标准对其进行病理分类及分级,对患者临床资料、病理学特点、免疫表型、治疗及预后情况进行分析。【结果】64例G-NEN患者男性多于女性,平均年龄为(65.7±9.01)岁,患者多数表现为腹痛。低级别G-NEN主要位于胃体,高级别G-NEN及混合性神经内分泌-非神经内分泌肿瘤(MiNEN)以贲门多见。不同病理类型患者年龄、肿瘤最大径、肿瘤部位、肿瘤数目、胃镜下形态、淋巴结转移情况、TNM分期比较,差异有统计学意义(P<0.05)。免疫组化突触素(Syn)的表达明显高于嗜铬素(CgA),差异具有统计学意义(P<0.05)。随访5~60个月,低级别G-NEN预后优于高级别G-NEN、MiNEN组患者(P<0.05),NET G 3与NEC、NEC与MiNEN预后比较,差异无统计学意义(P>0.05)。【结论】G-NEN以老年男性多见,主要表现为腹痛,不同病理类型G-NEN具有不同的临床病理特点及生物学行为,高级别G-NEN与MiNEN患者预后较差。【Objective】To analyze the clinicopathological characteristics and prognosis of gastric Neuroendocrine tumor(G-NEN).【Methods】A total of 64 cases of G-NEN in Yancheng Third People's Hospital from June 2016 to January 2022 were retrospectively analyzed.According to the fifth edition of the WHO digestive system tumor classification standard in 2019,their pathological classification and grading were carried out.Their clinical data,pathological characteristics,immunophenotype,treatment and prognosis were analyzed.【Results】Sixty-four G-NEN patients had more males than females,with an average age of(65.7±9.01)years.Most patients presented with abdominal pain.Low grade G-NEN was mainly located in the gastric body,while high grade NEN and MiNEN were more common in the cardia.There were statistically significant differences in age,maximum tumor diameter,tumor location,number of tumors,morphology under gastroscopy,lymph node metastasis,and TNM staging among patients with different pathological types(P<0.05).The expression of Syn in immunohistochemistry was significantly higher than that of CgA,and the difference was statistically significant(P<0.05).Following up for 5-60 months,the prognosis of low-grade NEN was better than that of patients in the high-level NEN and MiNEN groups(P<0.05).There was no statistically significant difference in the prognosis between NET G 3 and NEC,NEC and MiNEN(P>0.05).【Conclusion】G-NEN is more common in elderly men,mainly manifested as abdominal pain.Different pathological types of G-NEN have different clinical and pathological characteristics and biological behaviors.High grade NEN and MiNEN have poor prognosis.

关 键 词：神经内分泌瘤/病理学 胃肿瘤/病理学 预后 

分 类 号：R735.2[医药卫生—肿瘤]