男性缺血性卒中患者发病早期血清褪黑素、超氧化物歧化酶水平预测病情转归的价值  

The values of serum melatonin and superoxide dismutase levels in the early stage in predicting the outcome of male ischemic stroke patients

作　　者：张海萍 王新宇 袁梅 ZHANG Hai-ping;WANG Xin-yu;YUAN Mei(Department of Neurology,Second Affiliated Hospital of Nanhua University,Hengyang Hunan 421000,China)

机构地区：[1]南华大学附属第二医院神经内科,湖南衡阳421000

出　　处：《临床和实验医学杂志》2023年第14期1474-1478,共5页Journal of Clinical and Experimental Medicine

基　　金：2019年湖南省教育厅一般项目(编号:19C1587)。

摘　　要：目的 分析男性急性缺血性卒中(AIS)患者发病早期血清褪黑素、超氧化物歧化酶(SOD)水平预测病情转归的价值。方法 回顾性选取2021年10月至2022年10月由南华大学附属第二医院神经内科收治的206例男性AIS患者作为研究对象,对其一般资料、入院当日血清褪黑素、SOD水平进行分析,于发病14 d时根据患者美国国立卫生研究院卒中量表(NIHSS)评分和改良Rankin量表(mRS)评分的治疗效果和伤残程度进行评价。将治疗效果为治愈、显效或有效的患者列为有效组(n=150),将治疗效果为无效或恶化的患者列为无效组(n=56)。将伤残等级为无伤残、轻度伤残或中度伤残的患者列为非重残组(n=158),将伤残等级为重度伤残或严重伤残的患者列为重残组(n=48)。分析血清褪黑素、SOD水平与治疗效果及伤残程度的相关性及预测价值。结果 不同治疗效果及伤残程度患者入院时血清褪黑素、SOD水平的整体差异均有统计学意义(P<0.05),其中,治疗效果为无效患者与治疗效果为恶化患者的血清褪黑素、SOD水平比较,差异无统计学意义(P>0.05),其余各组之间比较,患者的血清褪黑素、SOD水平比较,差异均有统计学意义(P<0.05)。Logistic多元回归模型进行分析结果显示,AIS患者的治疗效果和伤残程度均与入院时的血清褪黑素、SOD水平具有相关性(P<0.05)。受试者工作特征曲线分析结果显示,血清褪黑素、SOD水平预测AIS患者治疗效果及伤残程度的曲线下面积差异均有统计学意义(P<0.05)。结论 男性AIS患者病程早期血清褪黑素、SOD水平的下降与治疗无效和重伤残有关,这两种血清学指标可用于辅助预测男性AIS患者的病情转归。Objective To analyze the values of serum melatonin and superoxide dismutase(SOD)levels in the early stage in predicting the outcome of male patients with acute ischemic stroke(AIS).Methods Two hundred and six male patients with AIS who were admitted to the Department of Neurology,the Second Affiliated Hospital of Nanhua University from October 2021 to October 2022 were retrospectively selected as the study subjects.The general data,the levels of serum melatonin and SOD on the next day of admission of the patients were analyzed.The therapeutic effects and the degree of disability were evaluated according to national institute of health stroke scale(NIHSS)score and modified Rankin scale(mRS)score at 14 days of onset.Patients with cured,significantly improved,or effective treatment effects were classified as the effective group(n=150),and patients with ineffective or worsened treatment effects were classified as the ineffective group(n=56).Patients with a disability level of no disability,mild disability,or moderate disability were classified as non severely disabled(n=158),while patients with a disability level of severe disability or severe disability were classified as severely disabled(n=48).The correlation of serum melatonin,SOD levels and therapeutic effects and the degree of disability and prediction values were analyzed.Results The overall differences of serum melatonin and SOD levels at admission in patients with different treatment effects and disability degrees was statistically significant(P<0.05).Among them,the difference of serum melatonin and SOD levels in patients with"ineffective"therapeutic effect and patients with"worsening"therapeutic effect was not statistically significant(P>0.05).The differences of serum melatonin and SOD levels in patients among other groups were statistically significant(P<0.05).Logistic multiple regression model showed that the therapeutic effects and disability degree of AIS patients were correlated with the serum melatonin and SOD levels at admission(P<0.05).The analysis

关 键 词：急性缺血性卒中 褪黑素 超氧化物歧化酶 治疗效果 伤残程度 病情转归 

分 类 号：R743.3[医药卫生—神经病学与精神病学]