循环肿瘤细胞检测联合^(131)碘全身显像评估甲状腺乳头状癌患者持续/复发状态的临床价值  

Clinical value of circulating tumor cell detection combined with ^(131)I whole body I scan in evaluating persistence/recurrence of patients with papillary thyroid carcinoma

作　　者：李泽阳 席永昌[2] 张建阳[2] 张建媛[2] 张力丹[2] LI Zeyang;XI Yongchang;ZHANG Jianyang;ZHANG Jianyuan;ZHANG Lidan(Graduate School,Chengde Medical University,Chengde 067000,Hebei,China;Department of Nuclear Medicine,Baoding No.1 Central Hospital,Baoding 071000,Hebei,China)

机构地区：[1]承德医学院研究生院,河北承德067000 [2]保定市第一中心医院核医学科,河北保定0710000

出　　处：《癌症进展》2023年第12期1310-1314,共5页Oncology Progress

基　　金：河北省医学科学研究课题计划(20191239);保定市科技计划自筹经费项目(2241ZF043)。

摘　　要：目的 分析循环肿瘤细胞(CTC)检测联合^(131)碘全身显像(^(131)I-WBS)评估甲状腺乳头状癌(PTC)患者持续/复发状态的临床价值,为PTC术后患者的健康管理提供参考。方法 选取54例PTC术后患者,其中持续/复发及转移性甲状腺乳头状癌(prmPTC)患者40例,无持续/复发及转移性甲状腺乳头状癌(non-prmPTC)患者14例。所有患者术后均进行CTC检测和^(131)I-WBS检查,分析CTC检测和^(131)I-WBS单独及二者联合对PTC患者持续/复发状态的评估价值。结果 不同年龄、性别、^(131)I-WBS结果的prmPTC患者的CTC阳性率比较,差异均无统计学意义(P﹥0.05)。CTC检测评估PTC患者持续/复发状态的灵敏度为80.00%,与中国临床肿瘤学会(CSCO)标准具有较高的一致性(Kappa值=0.675)。^(131)I-WBS评估PTC患者持续/复发状态的灵敏度为65.00%,与CSCO标准具有中度一致性(Kappa值=0.444)。CTC检测联合^(131)I-WBS评估PTC患者持续/复发状态的灵敏度为100%,与CSCO标准具有高度一致性(Kappa值=0.951)。CTC检测联合^(131)I-WBS评估PTC患者持续/复发状态的灵敏度、准确度及一致性均高于CTC检测和^(131)I-WBS单独检查。结论 CTC检测联合^(131)I-WBS能较为早期、准确地预测PTC持续/复发情况,为PTC患者的临床诊疗、预后评估提供参考依据。Objective To analyze the clinical value of circulating tumor cell(CTC)detection combined with ^(131)I-whole body scan(^(131)I-WBS)in evaluating persistence/recurrence of patients with papillary thyroid carcinoma(PTC)to provide reference for health management after PTC surgery.Method A total of 54 postoperative patients with PTC were selected,in which 40 cases were persistence/recurrence and metastatic PTC(prmPTC)and 14 cases were non-prmPTC.All patients received CTC and ^(131)I-WBS detection to analyze the value of single or combined detection of CTC detection and ^(131)I-WBS in evaluating persistence/recurrence in PTC.Result There were no significant differences in the positive rate of CTC in prmPTC patients with different age,sex and ^(131)I-WBS results(P>0.05).The sensitivity of CTC detection in evaluating the persistence/recurrence of PTC patients was 80.00%,which was in high consistency with the Chinese Soci-ety of Clinical Oncology(CSCO)criteria(Kappa value=0.675).The sensitivity of ^(131)I-WBS was 65.00%,which has mod-erate consistency with CSCO criteria(Kappa value=0.444).The sensitivity of CTC+^(131)I-WBS was 100%,which was high-ly consistent with CSCO criteria(Kappa value=0.951).The sensitivity,accuracy and consistency of CTC+^(131)I-WBS were significantly higher than single detection.Conclusion CTC+^(131)I-WBS can relatively early and accurately predict the per-sistence/recurrence of PTC,providing reference for clinical diagnosis,treatment and prognostic evaluation of PTC patients.

关 键 词：甲状腺乳头状癌 ^(131)碘全身显像 循环肿瘤细胞 

分 类 号：R736.1[医药卫生—肿瘤]