早期乳腺癌保乳术后瘤床不同补量放疗模式的疗效及安全性  

Efficacy and safety of different supplementary radiotherapy modes in the tumor bed after breast-conserving surgery for early breast cancer

作　　者：张梦[1] 柔倩 刘莹[1] 孜那提·努尔太 成芳[1] ZHANG Meng;ROU Qian;LIU Ying;Zinati·Nuertai;CHENG Fang(Department of Special Needs,Affiliated Cancer Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang,China)

机构地区：[1]新疆医科大学附属肿瘤医院特需科,乌鲁木齐8300110

出　　处：《癌症进展》2023年第12期1323-1326,1352,共5页Oncology Progress

摘　　要：目的 比较早期乳腺癌保乳术后全乳大分割放疗序贯瘤床大分割补量与瘤床常规分割补量的疗效及安全性。方法 按照瘤床补量放疗模式的不同将120例早期乳腺癌保乳术后全乳大分割放疗患者分为瘤床大分割组(n=30,序贯瘤床大分割补量870 cGy/3 f)和瘤床常规分割组(n=90,序贯瘤床常规分割补量1000 cGy/5 f)。比较两组患者的乳房美容效果、不良反应发生率、住院时间及预后。结果 放疗后1、6个月,两组患者的乳房美容效果优良率比较,差异均无统计学意义(P>0.05)。两组患者骨髓抑制、急性皮肤不良反应、晚期皮肤不良反应、放射性肺炎发生率比较,差异均无统计学意义(P>0.05)。两组患者的住院时间比较,差异无统计学意义(P>0.05)。两组患者的2年局部控制率和生存率均为100%。结论 早期乳腺癌保乳术后全乳大分割放疗已成为目前放疗的主流模式,序贯瘤床大分割补量与序贯瘤床常规分割补量的乳房美容效果和不良反应均无明显差异,患者的2年局部控制率及生存率均较高。在瘤床区域有钛夹标记的前提下,可优先选择更精准的三维适形调强放疗技术进行大分割瘤床补量放疗。Objective To compare the efficacy and safety of whole-breast hypofractionated radiotherapy sequential tumor bed hypofractionated supplementation and tumor bed conventional fractionation supplementation for early breast cancer after breast-conserving surgery.Method A total of 120 patients with early breast cancer undergoing breast-con-serving surgery and whole-breast hypofractionation radiotherapy were divided into tumor bed hyperfractionation group(n=30,sequential tumor bed hyperfractionation supplementation dose of 870 cGy/3 f)and tumor bed conventional frac-tionation group(n=90,sequential tumor bed conventional fractionation supplementation dose of 1000 cGy/5 f)according to different modes of tumor bed supplementation radiotherapy.The breast cosmetic effect,incidence of adverse events,hospitalization time,and prognosis were compared between the two groups.Result At one and six months after the ra-diotherapy,there was no statistically significant difference in the rate of good breast cosmetic effect between the two groups(P>0.05).There were no significant differences in the incidence of myelosuppression,acute skin adverse events,late skin adverse reactions,and radiation pneumonitis between the two groups(P>0.05).There was no significant differ-ence in the hospitalization time between the two groups(P>0.05).The 2-year local control rate and survival rate were 100%in both groups.Conclusion Whole-breast hypofractionation radiotherapy after breast-conserving surgery for early breast cancer has become the mainstream mode of radiotherapy.There were no significant differences in the breast cos-metic effect and adverse events between sequential tumor bed hyperfractionation supplementation and tumor bed conven-tional fractionation supplementation,and the 2-year local control rate and survival rate of the patients were both high.On the premise that the tumor bed area is marked with titanium clips,a more accurate three-dimensional conformal intensity-modulated radiotherapy technique could be preferred for tumor bed hyperfr

关 键 词：早期乳腺癌 保乳术 大分割放疗 常规分割放疗 瘤床标记 疗效 

分 类 号：R737.9[医药卫生—肿瘤]