乳腺区段切除术联合腋淋巴结清扫术对早期乳腺癌患者生活质量及预后的影响  

Effect of segmental mastectomy combined with axillary lymph node dissection on quality of life and prognosis of early breast cancer patients

作　　者：吉文仲[1] 刘春丽 陈建中[1] JI Wenzhong;LIU Chunli;CHEN Jianzhong(Department of Breast Surgery,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Department of Ultrasound Medicine,the Affiliated Cancer Hospital of Zhengzhou University/He’nan Cancer Hospital,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学第二附属医院乳腺外科,郑州450000 [2]郑州大学附属肿瘤医院/河南省肿瘤医院超声科,郑州4500000

出　　处：《癌症进展》2023年第12期1327-1329,1361,共4页Oncology Progress

基　　金：2018年度河南省医学科技攻关计划项目(2018020483)。

摘　　要：目的 探讨乳腺区段切除术联合腋淋巴结清扫术对早期乳腺癌患者生活质量及预后的影响。方法依据治疗方式的不同将89例早期乳腺癌患者分为观察组(n=47)和对照组(n=42),对照组患者给予乳腺癌改良根治术联合腋窝淋巴结清扫术治疗,观察组患者给予乳腺区段切除术联合腋窝淋巴结清扫术治疗。比较两组患者的围手术期相关指标、生活质量[乳腺癌患者生命质量测定量表(FACT-B)]、并发症发生情况及预后情况。结果观察组患者切口长度明显短于对照组,术中出血量明显少于对照组,手术时间、住院时间均明显短于对照组,差异均有统计学意义(P﹤0.01)。治疗后,两组患者FACT-B量表评分均高于本组治疗前,且观察组患者FACT-B量表评分高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者并发症总发生率为6.38%,低于对照组患者的21.43%,差异有统计学意义(P﹤0.05)。随访1年,两组患者生存、复发、转移情况比较,差异均无统计学意义(P﹥0.05);随访3年,两组患者复发、转移情况比较,差异均无统计学意义(P﹥0.05);观察组患者3年生存率为95.74%,明显高于对照组患者的76.19%,差异有统计学意义(P﹤0.01)。结论 乳腺区段切除术联合腋淋巴结清扫术可改善乳腺癌患者的术后生活质量及总生存率,效果显著。Objective To observe the effect of segmental mastectomy combined with axillary lymph node dissection on quality of life and prognosis of patients with early stage breast cancer.Method A total of 89 patients with early-stage breast cancer were divided into the observation group(n=47,received segmental mastectomy+axillary lymph node dis-section)and control group(n=42,received modified radical mastectomy+axillary lymph node dissection)according to the treatment methods.The perioperative surgery-related indicators,quality of life[functional assessment of cancer thera-py-breast(FACT-B)],complications and prognosis were compared between the two groups.Result The incision length of the observation group patients was significantly shorter than that of the control group,and the intraoperative bleeding was significantly less than that of the control group,the surgical time and hospitalization time were significantly shorter than those of the control group,and the differences were statistically significant(P<0.01).After treatment,the FACT-B scale score of both groups were higher than those before the treatment,and the FACT-B scale score of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was 6.38%,lower than 21.43%in the control group,the difference was statisti-cally significant(P<0.05).After one-year follow-up,there were no statistically significant differences in survival,recur-rence,and metastasis between the two groups(P>0.05).After 3-year follow-up,there were no statistically significant dif-ferences in recurrence and metastasis between the two groups(P>0.05).The 3-year survival rate of the observation group was 95.74%,significantly higher than 76.19%of the control group,the difference was statistically significant(P<0.01).Conclusion Segmental mastectomy combined with axillary lymph node dissection can improve the postoperative quality of life and overall survival rate of patients with br

关 键 词：乳腺区段切除术 腋淋巴结清扫术 早期乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]