血清人附睾蛋白4、叶酸受体1水平与上皮性卵巢癌患者临床特征和预后的关系  

Relationship between serum levels of human epididymis protein 4,folate receptor,1 and the clinical characteristics and prognosis of patients with epithelial ovarian cancer

作　　者：郭君红 郭玉琪 王倩 GUO Junhong;GUO Yuqi;WANG Qian(First Department of Obstetrics,Kaifeng Obstetrics and Gynecology Hospital,Kaifeng 475000,He’nan,China)

机构地区：[1]开封市妇产医院产一科,河南开封4750000

出　　处：《癌症进展》2023年第12期1362-1364,1388,共4页Oncology Progress

基　　金：2018年度河南省医学科技攻关计划项目(2018010021)。

摘　　要：目的 探讨血清人附睾蛋白4(HE4)、叶酸受体1(FOLR1)水平与上皮性卵巢癌患者临床特征和预后的关系。方法 选取120例上皮性卵巢癌患者,采用酶联免疫吸附试验检测血清HE4、FOLR1水平。收集患者的临床资料,比较不同临床特征上皮性卵巢癌患者的血清HE4、FOLR1水平。随访2年,采用Logistic回归模型分析上皮性卵巢癌患者预后的影响因素。结果 国际妇产科联盟(FIGO)分期为Ⅲ~Ⅳ期、有淋巴结转移上皮性卵巢癌患者的血清HE4、FOLR1水平均高于FIGO分期为Ⅰ~Ⅱ期、无淋巴结转移患者,差异均有统计学意义(P﹤0.05)。随访2年,120例患者中,生存56例,死亡64例。单因素分析显示,FIGO分期、淋巴结转移情况、血清HE4水平、血清FOLR1水平均可能是上皮性卵巢癌患者预后的影响因素(P﹤0.01)。多因素Logistic回归分析显示,FIGO分期、淋巴结转移情况、血清HE4水平、血清FOLR1水平均是上皮性卵巢癌患者预后的独立影响因素(P﹤0.01)。结论 血清HE4、FOLR1水平与上皮性卵巢癌患者的FIGO分期、淋巴结转移情况有关,HE4、FOLR1可作为预测上皮性卵巢癌患者预后的生物标志物,具有重要的临床意义。Objective To investigate the relationship between serum levels of human epididymis protein 4(HE4),fo-late receptor 1(FOLR1)and the clinical characteristics and prognosis of patients with epithelial ovarian cancer.Method A total of 120 patients with epithelial ovarian cancer were selected.Serum HE4 and FOLR1 levels were detected by en-zyme-linked immunosorbent assay.The clinical data of the patients were collected,and the serum HE4 and FOLR1 levels of epithelial ovarian cancer patients with different clinical characteristics were compared.Follow-up for 2 years,the Lo-gistic regression model was used to analyze the prognostic factors of patients with epithelial ovarian cancer.Result The levels of serum HE4 and FOLR1 in epithelial ovarian cancer patients of International of Gynecology and Obstetrics(FIGO)stage III-IV,with lymph node metastasis were higher than those of FIGO stage I-II,without lymph node metasta-sis,and the differences were statistically significant(P<0.05).During the 2-year follow-up,among 120 patients,56 sur-vived and 64 died.Univariate analysis indicated that FIGO stage,lymph node metastasis,serum HE4 level,and serum FOLR1 level may be influencing factors for the prognosis of patients with epithelial ovarian cancer(P<0.01).Multivari-ate Logistic regression analysis showed that FIGO stage,lymph node metastasis,serum HE4 level,and serum FOLR1 lev-el were independent factors for the prognosis of epithelial ovarian cancer patients(P<0.01).Conclusion Serum HE4 and FOLR1 levels are related to FIGO stage and lymph node metastasis of epithelial ovarian cancer patients.HE4 and FOLR1 could be used as biomarkers to predict the prognosis of patients with epithelial ovarian cancer,which has important clini-cal value.

关 键 词：人附睾蛋白4 叶酸受体1 上皮性卵巢癌 预后 

分 类 号：R737.31[医药卫生—肿瘤]