MAGE-A在胃癌患者中阳性表达与临床病理特征关系的meta分析  

Meta-analysis of the relationship between positive expression of MAGE-A and clinicopathological features in patients with gastric cancer

作　　者：郑强 赖佳敏 刘旭东 杜鹏 赵斌[1] 程志斌[1] ZHENG Qiang;LAI Jiamin;LIU Xudong;DU Peng;ZHAO Bin;CHENG Zhibin(Department of General Surgery,The Second Hospital of Lanzhou University,Lanzhou,Gansu 730030,China)

机构地区：[1]兰州大学第二医院普通外科,兰州730030

出　　处：《重庆医学》2023年第15期2351-2356,共6页Chongqing medicine

基　　金：甘肃省高等学校创新基金项目(2020B-032)。

摘　　要：目的探讨黑色素瘤抗原相关基因-A(MAGE-A)在胃癌患者中阳性表达与其临床病理特征的相关性。方法按照纳入标准和排除标准检索收集PubMed、Web of science、Cochran图书馆、中国知网、维普、万方医学等数据库从建库至2022年3月1日MAGE-A与胃癌临床病理特征相关的所有研究,评价各研究方法学质量,并进行meta分析,探讨胃癌患者MAGE-A表达与胃癌患者性别、TNM分期、淋巴结转移、肿瘤分化程度、肿瘤侵犯深度、癌细胞远处转移的关系,并分析其偏倚情况和敏感性。结果纳入文献12篇,样本量1828例。meta分析结果显示:胃癌患者MAGE-A阳性表达与男性(OR=1.60,95%CI:1.27~2.02,P<0.001)、Ⅰ~Ⅱ期(OR=0.53,95%CI:0.42~0.67,P<0.001)、无淋巴结转移(OR=0.25,95%CI:0.13~0.47,P<0.001)、侵犯深度为T1~T2(OR=0.50,95%CI:0.32~0.80,P=0.004)有关;与胃癌患者的分化程度(OR=0.71,95%CI:0.40~1.28,P=0.254)、远处转移(OR=0.58,95%CI:0.31~1.10,P=0.096)无关。结论男性胃癌患者较女性更易出现MAGE-A阳性表达,且MAGE-A阳性表达的胃癌患者常处于疾病的早期阶段。Objective To investigate the correlation between the positive expression of the melanoma antigen-associated gene-A(MAGE-A)and its clinicopathological features in patients with gastric cancer.Methods According to the inclusion and exclusion criteria,we collected relevant research on MAGE-A and clinicopathological features of gastric cancer from PubMed,Web of Science,Cochrane Library,CNKI,VIP,Wanfang Medicine,and other databases from the establishment of the database until March 1,2022.The methodological quality of each study was evaluated,and a meta-analysis was performed.The study aimed to investigate the correlation between the expression of MAGE-A in patients with gastric cancer and various factors,including gender,TNM stage,lymph node metastasis,degree of tumor differentiation,depth of tumor invasion,and distant metastasis.Additionally,the study analyzed any potential bias and sensitivity.Results Twelve articles were included,with a sample size of 1828 cases.The results showed that the positive expression of MAGE-A in patients with gastric cancer was associated with male sex(OR=1.60,95%CI:1.27-2.02,P<0.001),stageⅠ-Ⅱ(OR=0.53,95%CI:0.42-0.67,P<0.001),no lymph node metastasis(OR=0.25,95%CI:0.13-0.47,P<0.001),and invasion depth of T1-T2(OR=0.50,95%CI:0.32-0.80,P=0.004),but no correlation with differentiation degree(OR=0.71,95%CI:0.40-1.28,P=0.254),distant metastasis(OR=0.58,95%CI:0.31-1.10,P=0.096)in patients with gastric cancer.Conclusion Male patients with gastric cancer exhibit a higher likelihood of MAGE-A positive expression compared to their female counterparts.Additionally,gastric cancer patients who display MAGE-A positive expression are frequently diagnosed in the early stages of the disease.

关 键 词：黑色素瘤抗原相关基因-A 胃癌 病理特征 预测指标 META分析 

分 类 号：R735.2[医药卫生—肿瘤]