Transcriptional regulation in the development and dysfunction of neocortical projection neurons  

作　　者：Ningxin Wang Rong Wan Ke Tang 

机构地区：[1]Precise Genome Engineering Center,School of Life Sciences,Guangzhou University,Guangzhou,Guangdong Province,China

出　　处：《Neural Regeneration Research》2024年第2期246-254,共9页中国神经再生研究（英文版）

基　　金：supported by Guangdong Provincial Basic and Applied Basic Research Fund,No.2021A1515011299(to KT)。

摘　　要：Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord.Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and synaptogenesis.These processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural activities.The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations.

关 键 词：autism spectrum disorders COGNITION DIFFERENTIATION excitatory circuits intellectual disability NEOCORTEX neurodevelopmental disorders projection neuron specification transcriptional regulation 

分 类 号：R338[医药卫生—人体生理学]