Recent advances in the application of MXenes for neural tissue engineering and regeneration  

作　　者：Menghui Liao Qingyue Cui Yangnan Hu Jiayue Xing Danqi Wu Shasha Zheng Yu Zhao Yafeng Yu Jingwu Sun Renjie Chai 

机构地区：[1]State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,Advanced Institute for Life and Health,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing,Jiangsu Province,China [2]Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China [3]Department of Oto-Rhino-Laryngology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China [4]First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,China [5]Department of Otolaryngology-Head and Neck Surgery,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui Province,China [6]Department of Otolaryngology Head and Neck Surgery,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan Province,China [7]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing,China [8]Beijing Key Laboratory of Neural Regeneration and Repair,Capital Medical University,Beijing,China

出　　处：《Neural Regeneration Research》2024年第2期258-263,共6页中国神经再生研究（英文版）

基　　金：supported by grants from the National Key R&D Program of China,Nos.2021YFA1101300,2021YFA1101803,2020YFA0112503;the National Natural Science Foundation of China,Nos.82030029,81970882,92149304;Science and Technology Department of Sichuan Province,No.2021YFS0371(all to RC)。

摘　　要：Transition metal carbides and nitrides(MXenes)are crystal nanomaterials with a number of surface functional groups such as fluorine,hydroxyl,and oxygen,which can be used as carriers for proteins and drugs.MXenes have excellent biocompatibility,electrical conductivity,surface hydrophilicity,mechanical properties and easy surface modification.However,at present,the stability of most MXenes needs to be improved,and more synthesis methods need to be explored.MXenes are good substrates for nerve cell regeneration and nerve reconstruction,which have broad application prospects in the repair of nervous system injury.Regarding the application of MXenes in neuroscience,mainly at the cellular level,the long-term in vivo biosafety and effects also need to be further explored.This review focuses on the progress of using MXenes in nerve regeneration over the last few years;discussing preparation of MXenes and their biocompatibility with different cells as well as the regulation by MXenes of nerve cell regeneration in two-dimensional and three-dimensional environments in vitro.MXenes have great potential in regulating the proliferation,differentiation,and maturation of nerve cells and in promoting regeneration and recovery after nerve injury.In addition,this review also presents the main challenges during optimization processes,such as the preparation of stable MXenes and long-term in vivo biosafety,and further discusses future directions in neural tissue engineering.

关 键 词：HYDROGELS MXenes nerve regeneration neural cells neural stem cells ORGANOIDS spiral ganglion neurons 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]