蛛网膜下腔出血后早期脑损伤机制与治疗  

Mechanism and treatment of early brain injury after subarachnoid hemorrhage

作　　者：王东森(综述) 吴庆建(审校)[2] WANG Dongsen;WU Qingjian(School of Clinical Medicine,Jining Medical University,Jining 272013,China;Department of Emergency,Jining NO.1 People's Hospital,Jining 272011,China)

机构地区：[1]济宁医学院临床医学院,济宁272013 [2]济宁市第一人民医院急诊科,济宁272011

出　　处：《济宁医学院学报》2023年第4期278-282,共5页Journal of Jining Medical University

基　　金：山东省自然科学基金面上项目(ZR2021MH133)。

摘　　要：蛛网膜下腔出血后早期脑损伤是指发生在血管痉挛前,蛛网膜下腔出血后72h内大脑发生的一系列变化,包括脑灌注变化、炎症反应、活性氧自由基的产生、皮质弥散去极化、血脑屏障破坏及神经细胞死亡等。本文主要总结了目前早期脑损伤发生的研究最新进展,旨在为蛛网膜下腔出血后早期脑损伤研究及治疗提供依据。Early brain injury(EBI)after Subarachnoid hemorrhage(SAH)refers to a series of changes in the brain within 72 hours after subarachnoid hemorrhage,which occurred before vasospasm,including cerebral perfusion,inflammatory response,generation of reactive oxygen species,cortical diffusion depolarization,destruction of blood-brain barrier and death of nerve cells.This article reviews the current progress of EBI to provide a theoretical foundation for the study of EBI after SAH.

关 键 词：蛛网膜下腔出血 早期脑损伤 病理生理机制 

分 类 号：R743.35[医药卫生—神经病学与精神病学]