Bioadaptable bioactive glass-β-tricalcium phosphate scaffolds with TPMS-gyroid structure by stereolithography for bone regeneration  

作　　者：Meng Li Jiawei Jiang Wenbin Liu Xiaolong Huang Xiaopei Wu Wenying Wei Hao Zhu Jinyong Zhang Jun Xiao Honglian Dai 

机构地区：[1]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan 430070, China [2]Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [3]Department of Orthopaedics, The Third Xiangya Hospital, Central South University, Changsha 410008, China [4]Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory, Xianhu Hydrogen Valley, Foshan 528200, China

出　　处：《Journal of Materials Science & Technology》2023年第24期54-65,共12页材料科学技术（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(Nos.2022YFB4601402);the National Natural Science Foundation of China(Nos.32201109,51772233);the Guangdong Basic and Applied Basic Research Foundation(Nos.2022B1515120052,2021A1515110557);the Key Basic Research Program of Shenzhen(No.JCYJ20200109150218836);the Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory(No.HJL202202A002)。

摘　　要：Bone defect repair remains a troubling problem in clinical orthopedics,which involves complex biological processes.Calcium phosphates(CaPs)have been widely used owing to their advantage of biocompatibility.However,single component and traditional fabrication methods cannot meet the requirements of bioadaptability during the tissue repair process.In this work,0%,5%,15%,25%wt%of BG-TCP(bioactive glass-β-tricalcium phosphate)bioresorbable scaffolds with triply-periodic minimal surfaces(TPMS)-gyroid structure were prepared by the stereolithography(SLA)technology.TPMS-gyroid structure provided an accurate mimicry of natural bone tissue,and the incorporation of BG improved the compressive strength ofβ-TCP matrix,matched with the defective bone(2–12 MPa).Rapid but tunable degradation kinetics(compared with pure TCP)of BG enabled the BG-TCP system to sh8ow adaptable biodegradability to new bone generation.In vitro studies have shown that composite scaffolds have better mechanical properties(7.82 MPa),and can released appropriate contents of calcium,phosphorous,and magnesium ions,which promoted the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)and angiogenic ability of endothelial progenitor cells(EPCs).Moreover,the in vivo assessment of rat femoral defect revealed that TPMS-structure-based TCP scaffolds accelerated bone ingrowth to the pores.Moreover,BG-TCP scaffolds,especially 15BG-TCP group,exhibited superior bone regeneration capacity at both 4 and 8 weeks,which achieved an optimal match between the rate of material degradation and tissue regeneration.In summary,this study provides insight into influences of bioactive components(BG)and bionic structures(TPMS)on the physical-chemical properties of materials,cell behavior and tissue regeneration,which offers a promising strategy to design bioadaptive ceramic scaffolds in the clinical treatment of bone defects.

关 键 词：Bioactive glass Tricalcium phosphate Triply periodic minimal surfaces STEREOLITHOGRAPHY OSTEOGENESIS 

分 类 号：TQ174.1[化学工程—陶瓷工业] TB383.1[化学工程—硅酸盐工业] R318.08[一般工业技术—材料科学与工程]