Inflammatory Biomarkers in Elite Cross-Country Skiers After a Competition Season:A Case-Control Study  

作　　者：Raakel Luoto Olli Ruuskanen Johanna K.Ihalainen Satu Pekkala Jukka Hintikka Noora Kanerva Matti Waris Olli J.Heinonen Maarit Valtonen 

机构地区：[1]Department of Paediatrics and Adolescent Medicine,Turku University Hospital and University of Turku,PL 52,20521 Turku,Finland [2]Faculty of Sport and Health Sciences,University of Jyväskylä,Jyväskylä,Finland [3]Department of Food and Nutrition,University of Helsinki,Helsinki,Finland [4]Institute of Biomedicine,Department of Clinical Virology,University of Turku,Turku University Hospital,Turku,Finland [5]Paavo Nurmi Centre and Unit for Health and Physical Activity,University of Turku,Turku,Finland [6]Finnish Institute of High Performance,KIHU,Rautpohjankatu,6,40700 Jyväskylä,Finland

出　　处：《Journal of Science in Sport and Exercise》2023年第3期254-262,共9页体育运动科学（英文）

基　　金：Open Access funding provided by University of Turku(UTU)including Turku University Central Hospital.Jenny and Antti Wihuri Foundation.

摘　　要：Purpose Whether elite athletes,who have been exposed to vigorous-intensity exercise combined with other stressors,have elevated systemic low-grade inflammation,remains largely unclear.To address this question,we studied the levels of six inflammatory cytokines as potential biomarkers of a low-grade inflammatory state in elite athletes after an 11-month train-ing and competition season.Methods We collected sera from 27 Finnish elite cross-country skiers and 27 gender-and age-matched,moderately-exer-cising controls.The serum concentrations of C-reactive protein(CRP),interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α),glycoprotein acetyls(GlycA),interleukin 10(IL-10),and interferon gamma(IFN-γ)cytokines were quantified as surrogate markers of low-grade inflammation.Results The athletes were found to have significantly lower concentrations of CRP(P=0.0232)and higher concentrations of IL-10,TNF-α,and IFN-γ(P=0.0097,P=0.0256,and P=0.0185,respectively)than the controls.No significant differences between athletes and controls were detected in the concentrations of IL-6 and GlycA.The inflammatory score(IS)did not differ significantly between athletes and controls.Conclusion The results of this study argued against the hypothesis of a significant chronic low-grade inflammation in response to prolonged high-performance exercise among elite endurance athletes.

关 键 词：ATHLETE BIOMARKER Chronic low-grade inflammation Exercise GlycA Inflammation 

分 类 号：G804[文化科学—运动人体科学]