Severe graft-versus-host disease post allogeneic hematopoietic stem cell transplantation due to loss of HLA heterozygosity in recipient lymphocytes after full graft rejection  

作　　者：Song Xue Lili Miao Zimu Gong Wenqiu Huang Yongping Zhang Fuhong Liu Jingbo Wang 

机构地区：[1]Department of Hematology,Aerospace Center Hospital,Peking University Aerospace School of Clinical Medicine,Beijing,China [2]Beijing Bo Fu Rui Gene Diagnostics Co.,Ltd,Beijing,China [3]Cancer Center,Houston Methodist Hospital,Houston,Texas,USA

出　　处：《Cancer Innovation》2023年第4期312-317,共6页肿瘤创新（英文）

摘　　要：Germ cell tumors complicated by hematological malignancy(HM)are a rare clinical phenomenon.Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is a potentially effective therapy,but graft-versus-host disease(GVHD)is a life-threatening complication.We report a case of a 13-year-old female patient diagnosed with germ cell tumors followed by acute lymphoblastic leukemia.After chemotherapy,she received allo-HSCT and her chimerism rate decreased rapidly to near zero by 6 months without evidence of HM recurrence.However,she developed severe,multiorgan GVHD-like manifestations.DNA analysis revealed the pathogenesis of GVHD to be loss of HLA heterozygosity in recipient hematopoietic cells.

关 键 词：CHIMERISM germcelltumors graft-versus-host disease HETEROZYGOSITY stemcell transplantation 

分 类 号：R733.7[医药卫生—肿瘤]