Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion  

作　　者：Qun Li Jinbiao Liu Huijie Liu Yue Sun Yingying Xu Kexin Wang Wenjing Huang Lan Liao Xiaolei Wang 

机构地区：[1]Affiliated Stomatological Hospital,Nanchang University,Nanchang,Jiangxi,330006,PR China [2]National Engineering Research Center for Bioengineering Drugs and the Technologies,Institute of Translational Medicine,Nanchang University,Nanchang,Jiangxi,330088,PR China [3]College of Chemistry and Chemical Engineering,Nanchang University,Nanchang,Jiangxi,330088,PR China [4]Jinggangshan University,Ji’an,Jiangxi,343009,PR China [5]Key Laboratory of Oral Biomedicine,Nanchang,Jiangxi,330006,PR China

出　　处：《Bioactive Materials》2023年第11期72-84,共13页生物活性材料（英文）

基　　金：the National Natural Science Foundation of China(No.31860263 to Xiaolei Wang;No.82160194 and No.81960492 to Lan Liao);Key Youth Project of Jiangxi Province(20202ACB216002 to Xiaolei Wang);Key Research and Development Program of Jiangxi Province(20212BBG73004 to Xiaolei Wang;20212BBG73022 to Lan Liao);Natural Science Foundation of Jiangxi Province(No.20181ACB20022 to Lan Liao).

摘　　要：Caries is considered to be the most prevalent non-communicable disease in humans, mainly deriving from acidogenic bacterial biofilm and resulting in the demineralization and decomposition of hard dental tissue. Herein, a composite responsive foam brace loaded with magnesium organic framework (MPC) is designed for caries prevention and tooth remineralization. MPC can intelligently release organic antibacterial molecules (gallic acid) and mineralized ions (Mg2+, Ca2+ and PO43 ) under acidic conditions (pH < 5.5) of biofilm infection, regulating pH and killing bacteria. Additionally, due to the excellent photothermal conversion efficiency, MPC can further enhance the destruction of bacterial biofilm by inhibiting virulence genes and destroying bacterial adhesion under near-infrared light irradiation (808 nm). More importantly, MPC can not only reverse the cariogenic environment at both pH and microbial levels, but also promote self-healing of demineralized teeth in terms of both the micro-structure and mechanical properties.

关 键 词：Photothermy pH-response REMINERALIZATION Caries prevention 

分 类 号：R78[医药卫生—口腔医学]