牙周健康与胃幽门螺杆菌感染相关性研究  

Correlation between periodontal health and helicobacter pylori infection in the stomach

作　　者：聂玉海 郑威楠 程守正 崔江雨 王淑琴 NIE Yuhai;ZHENG Weinan;CHENG Shouzheng;CUI Jiangyu;WANG Shuqin(School of Stomatology,Xinxiang Medical University,Xinxiang,Henan 453003,China;Department of Human Anatomy,Chengdu Medical College,Chengdu,Sichuan 610500,China;School of Stomatology,Sichuan University,Chengdu,Sichuan 610044,China;General Department of Micro Medicine/Chengdu High-tech Center,Chengdu,Sichuan 610095,China)

机构地区：[1]新乡医学院口腔医学院,河南新乡453003 [2]成都医学院人体解剖学教研室,四川成都610500 [3]四川大学华西口腔医学院,四川成都610044 [4]微医全科/成都高新中心,四川成都610095

出　　处：《现代医药卫生》2023年第15期2579-2583,共5页Journal of Modern Medicine & Health

基　　金：发育与再生四川省重点实验室研究基金项目(SYS18-07)。

摘　　要：目的探讨牙周健康与胃幽门螺杆菌(Hp)感染的相关性。方法选取2019年1月至2022年5月经微医全科/成都高新中心检测出的胃Hp感染的体检者1208例,其中合并慢性牙龈炎409例,合并慢性牙周炎265例,牙周健康者534例。从对应疾病患者中采用随机数字表法选取120例合并慢性牙龈炎的体检者作为试验组1,120例合并慢性牙周炎的体检者作为试验组2,120例牙周健康的体检者作为对照组。以13 C尿素呼气试验检测数值——DOB值评估3组患者胃Hp感染程度,并进行两两比较其差异。同时,根据牙周袋深度及附着丧失程度探讨慢性牙周炎病变程度(轻、中、重度)对DOB值的影响。结果3组患者年龄、性别比较,差异均无统计学意义(P>0.05)。对照组患者DOB值小于试验组1,但差异无统计学意义(P>0.05);对照组、试验组1患者DOB值均明显小于试验组2,差异均有统计学意义(P<0.05);慢性牙周炎患者DOB值随牙周严重程度增加而增加,差异有统计学意义(P<0.05)。结论胃Hp感染程度与慢性牙龈炎的相关性不显著,但与慢性牙周炎密切相关,且不同牙周炎感染程度患者具有差异性。为胃Hp感染的治疗研究提供了一定的参考依据。Objective To investigate the correlation between periodontal health and helicobacter pylori(Hp)infection in the stomach.Methods From January 2019 to May 2022,a total of 1208 cases of Hp infection in stomach were selected by General Department of Micro Medicine/Chengdu High-tech Center,including 409 cases with chronic gingivitis,265 cases with chronic periodontitis,and 534 cases with healthy periodontal.From the patients with corresponding diseases,using the randomized numerical table method,120 subjects with combined chronic gingivitis were randomly selected as experimental group 1,120 subjects with combined chronic periodontitis as experimental group 2,and 120 subjects with healthy periodontium as control group.The degree of Hp infection in the stomach of the three groups was evaluated by Donation Of Brain(DOB)value,which was the detection value of 13 C urea breath test,and the differences were compared in pairs.At the same time,according to the depth of periodontal pocket and the degree of attachment loss,the influence of the degree of chronic periodontitis(mild,moderate and severe)on DOB value was discussed.Results There were no significant differences in age and sex among the three groups(P>0.05).The DOB value in the control group was lower than that in experimental group 1,but there was no statistical difference(P>0.05).The DOB value in the control group and experimental group 1 was significantly smaller than that in experimental group 2,and the differences were statistically significant(P<0.05).The DOB value of patients with different degrees of chronic periodontitis increased with the increase of periodontal severity,and the differences were statistically significant(P<0.05).Conclusion The degree of Hp infection in the stomach is not closely related to chronic gingivitis,but closely related to chronic periodontitis,and there are differences among patients with different degrees of periodontitis infection.It provides a certain reference for the treatment and research of gastric Hp infection.

关 键 词：牙周炎 牙龈炎 幽门螺杆菌 感染 胃 

分 类 号：R781[医药卫生—口腔医学] R378[医药卫生—临床医学]