基于锥形束CT数据估算颌骨骨量变化的方法研究  

Study on the estimation of jaw bone mass change based on cone beam CT imaging

作　　者：李伟志[1] 王瑞永[1] 刘敏[2] 顾晓宇[3] 乔惠婷[4] LI Wei-zhi;WANG Rui-yong;LIU Min;GU Xiao-yu;QIAO Hui-ting(Department of Stomatology,Beijing Haidian Hospital,Beijing 100080,China;Preventive Dentistry,Beijing Stomatological Hospital Capital medical university,Beijing 100050,China;Department of Prosthodontics,Shanghai Ninth People's Hospital,Shanghai JiaoTong University School of Medicine,Shanghai Institue of Stomatology,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China;School of Biological Science and Medical Engineering,Beihang University,Beijing Advances Innovation Center for Biomedical Engineering,Beijing 100191,China)

机构地区：[1]北京市海淀医院口腔科,北京100080 [2]首都医科大学附属北京口腔医院预防科,北京100050 [3]上海交通大学医学院附属第九人民医院口腔修复科、上海市口腔医学研究所、上海市口腔医学重点实验室,上海200011 [4]北京航空航天大学生物与医学工程学院、北京市生物医学工程高精尖创新中心,北京100191

出　　处：《口腔颌面修复学杂志》2023年第3期193-198,共6页Chinese Journal of Prosthodontics

基　　金：北京市海淀医院青年项目(项目编号:KYQ2019011)。

摘　　要：目的:建立一种基于锥形束CT二次成像数据,对个体颌骨骨量变化情况进行半自动估算的有效方法。方法:首先获得同一研究对象下颌骨骨量变化前后的两套锥形束CT三维图像数据,对这两套三维图像采用计算机程序化算法进行最大互信息图像配准,配准后做差得到差异图像,针对差异图像进行阈值分割,分割后得到下颌骨骨量变化的区域,然后计算该区域的体素数量,进而定量定位估算颌骨在两次成像之间的骨量变化。本文在提出方法的同时,用人类湿下颌骨标本和猪肋骨块进行骨量变化估算的平台实验,以猪肋骨块的光学扫描结果为真实骨量变化的参照,对算法进行定量校正。结果:针对8组不同骨量变化图像,本文所提出的方法能有效地估算出骨量变化量,并给出其定位,通过光学扫描结果对算法进行校正,修正系数为0.8044,校正后估算结果与真值的确定系数为0.988。结论:本文所提出的方法可基于两次锥形束CT成像数据有效地定量定位估算出同一研究对象的颌骨骨量变化。该方法为口腔科相关治疗的疗效评价及改进提供了一种半自动定量定位的分析手段。Objective:To estimate individual changes of jaw bone mass,an effective semi-automatic method is established based on two times cone beam CT imaging.Methods:First,the maxillofacial cone-beam CT images are obtained from the same subject before and after the jaw bone mass change.Registration of these two sets of images is performed based on maximum mutual information,and the difference images are obtained.Then the changes in mandibular are segmented by threshold to quantitatively estimates the changes of the jaw bones between two images.While proposing the method,this paper uses human wet mandibular specimens and pig rib blocks to carry out a platform experiment for estimating bone mass changes,and uses optical scanning of pig rib blocks to obtain actual bone mass changes,and quantitatively correct the algorithm.Results:For the 8 groups of different bone mass change images,the method proposed in this paper can effectively estimate the volume and position of bone mass change.The algorithm is corrected by the results of optical scanning,the correction coefficient is 0.8044,and R-square is 0.988.Conclusion:The method proposed in this paper can effectively estimate the change of jaw bone mass based on 2 cone beam CT images,which provides a quantitative analysis method for maxillofacial surgery and treatment.

关 键 词：颌骨 牙槽骨 骨量变化 锥形束CT 定量算法 

分 类 号：R782.051[医药卫生—口腔医学]