PM_(2.5)致心血管系统损伤及机制研究进展  

Research progress on cardiovascular system injury caused by PM_(2.5)and related mechanisms

作　　者：王涵 劳文艳 李松霖 秦菲[1] 吴国浩 WANG Han;LAO Wen-Yan;LI Song-Lin;QIN Fei;WU Guo-Hao(College of Biochemical Engineering,Beijing Union University,Beijing 100023,China;Scientific Research Institute of Beijing Tongrentang Co.,Ltd,Beijing 100011,China)

机构地区：[1]北京联合大学生物化学工程学院,北京100023 [2]北京同仁堂股份有限公司科学研究所,北京100011

出　　处：《生命科学》2023年第7期870-875,共6页Chinese Bulletin of Life Sciences

基　　金：北京市自然科学基金项目(7192098)。

摘　　要：细颗粒物(particulate matter,PM_(2.5))是一种严重的环境污染物质。它对机体多系统都有不良影响,而心血管系统是其主要目标,因此PM_(2.5)暴露对心血管系统的影响越来越受到人们的关注。许多研究表明PM_(2.5)与心血管疾病(cardiovascular disease,CVD)的发病率和死亡率之间具有明确的因果关系。PM_(2.5)通过氧化应激、炎症、线粒体损伤、细胞凋亡等机制对心血管系统造成损伤,成为CVD的主要死亡危险因素。本文从流行病学、动物、细胞水平的角度总结了PM_(2.5)诱导CVD机制的研究现状,为更好地了解心血管致病机理,提高公众对PM_(2.5)对CVD危害的认识,为预防、管理、治疗PM_(2.5)引起的CVD提供科学依据。Cardiovascular system is the main target of fine particulate matter(PM_(2.5)),a serious environmental contaminant,which has adverse health effects on multiple body systems.Therefore the influence of PM_(2.5)exposure to cardiovascular system has drawn more and more attention.A unequivocal link between PM_(2.5)and morbidity and mortality of cardiovascular diseases(CVD)has been proved by a number of studies.Cardiovascular system injury was induced by PM_(2.5)through mechanisms of oxidative stress,inflammation,mitochondrial dysfunction and cell apoptosis,etc.,thus PM_(2.5)has become the main risk factor for CVD death.Current researches on mechanisms of PM_(2.5)-induced CVD were summarized from the perspectives of human epidemiology,animal and cell,to improve the public awareness to CVD induced by PM_(2.5)and provide a scientific basis for the prevention,management and treatment of CVD caused by PM_(2.5).

关 键 词：PM_(2.5) 心血管系统损伤 氧化应激 炎症 线粒体损伤 细胞凋亡 

分 类 号：R122[医药卫生—环境卫生学] R54[医药卫生—公共卫生与预防医学]