铁死亡在肿瘤放射生物学效应中的研究进展  

Research progress on radiobiological effects of ferroptosis in cancer

作　　者：王天翔 杜鸣宇 章平川 尹丽[1,2,3] 何侠[1,2,3] Wang Tianxiang;Du Mingyu;Zhang Pingchuan;Yin Li;He Xia(The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research,Nanjing 210009,China;The Fourth Clinical Medical College of Nanjing Medical University,Nanjing 210000,China;The Collaborative Innovation Center for Cancer Personalized Medicine of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学附属肿瘤医院/江苏省肿瘤医院/江苏省肿瘤防治研究所,南京210009 [2]南京医科大学第四临床医学院,南京210000 [3]南京医科大学肿瘤个体化医学协同创新中心,南京210000

出　　处：《中华放射肿瘤学杂志》2023年第8期742-747,共6页Chinese Journal of Radiation Oncology

摘　　要：铁死亡是近年来发现的一种调节性细胞死亡新形式,表现为铁依赖性的、以多不饱和脂肪酸磷脂过氧化为特征的细胞死亡。最近研究发现放射治疗可以通过电离辐射诱导肿瘤细胞铁死亡,靶向铁死亡可与放射线协同发挥抑癌作用,不仅进一步深化了放射生物学的内涵,也为肿瘤放疗增敏提供了新的视角思路。本篇综述对铁死亡的发生及防御进行系统总结,重点分析了铁死亡在肿瘤细胞放射生物学效应中的关键作用及铁死亡在放疗增敏中的潜在应用前景。Ferroptosis is a new form of regulated cell death discovered in recent years,which is iron-dependent cell death characterized by peroxidation of polyunsaturated fatty acid phospholipids.Recent studies have shown that radiotherapy can induce ferroptosis in cancer cells via ionizing radiation.Targeting ferroptosis plays a synergistic role in tumor suppression with radiation,which not only further deepens the connotation of radiobiology,but also provides a new perspective for tumor radiosensitization.This review systematically summarizes the occurrence and defense of ferroptosis,focusing on the key role of ferroptosis in the radiobiological effects of tumor cells and the potential application of ferroptosis in radiosensitization.

关 键 词：铁死亡 肿瘤 恶性 放射生物学 辐射耐受性 

分 类 号：R730.55[医药卫生—肿瘤]