儿童恶性肿瘤初诊期肠内营养支持对初次化疗进程的影响研究  

Study on the impact of enteral nutrition support on the progression of chemotherapy in children with malignant tumors at the first diagnosis

作　　者：金仙梅[1] 李炳荣[3] 王锐[2] JIN Xianmei;LI Bingrong;WANG Rui(Department of Pediatric Oncology,the First Hospital of Jilin University;Department of Pharmacy,Jilin Cancer Hospital,Changchun 130012;Department of Pharmacy,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院小儿肿瘤科,长春130061 [2]吉林大学第一医院药品供应部,长春130061 [3]吉林省肿瘤医院药剂科,长春130012

出　　处：《中国小儿血液与肿瘤杂志》2023年第3期170-175,180,共7页Journal of China Pediatric Blood and Cancer

摘　　要：目的探讨肠内营养支持对恶性肿瘤患儿营养状态及初次化疗期并发症的影响。方法选取2020年1月—12月共111例初次确诊各型恶性肿瘤患儿为研究对象,随机分为肠内营养干预组和对照组,观察2组化疗前后营养相关指标变化及对化疗并发症的影响。结果初次诊断时42例(37.8%)存在高度营养风险,69例(62.2%)存在中度营养风险,化疗后干预组HAZ、WAZ及BAZ均高于对照组;化疗后干预组TG、Alb、PA及WBC、HGB、AST、ALT、CHE较相应对照组变化程度小;干预组首次入院平均药品费用、特殊限制级别抗生素使用比例及血液制品使用比例均低于相应对照组。结论恶性肿瘤患儿初次诊断时营养不良发生率较高,化疗期间给予肠内营养支持有助于维持患儿营养状态,一定程度上增加化疗耐受性。Objective To explore the impact of enteral nutrition support on the nutritional status and complications of primary chemotherapy in children with malignant tumors.Methods 111 children with initially diagnosed with various types of malignant tumors from January to December 2021 were employed and randomly divided into an enteral nutrition intervention group and a control group.The changes in nutritional related indicators before and after chemotherapy and their impact on chemotherapy complications were observed.Results At the initial diagnosis,42 cases(37.8%)had a high nutritional risk,while 69 cases(62.2%)had a moderate nutritional risk.After chemotherapy,the HAZ,WAZ,and BAZ of the two intervention groups were higher than those in the control group;After chemotherapy,the changes in TG,Alb,PA,WBC,HGB,AST,ALT,CHE in the intervention groups were less severe compared to those in the corresponding control group;The average first-time hospitalization drug costs,proportion of special restricted antibiotic use,and proportion of blood products use in both intervention groups were lower than those in the corresponding control group.Conclusions The incidence of malnutrition in children with malignant tumors is relatively high at the initial diagnosis.Enteral nutrition support during chemotherapy can help maintain the nutritional status of the children and increase chemotherapy tolerance to a certain extent.

关 键 词：恶性肿瘤 儿童 肠内营养 化疗 

分 类 号：R730.5[医药卫生—肿瘤] R459.3[医药卫生—临床医学]