脑白质变化与多发性硬化症的研究进展  

Progress in brain white matter changes and multiple sclerosis

作　　者：李邦静 巨红燕[1] 唐珊珊 LI Bangjing;JU Hongyan;TANG Shanshan(West China Hospital Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院,四川成都610041

出　　处：《中国实用神经疾病杂志》2023年第8期1046-1050,共5页Chinese Journal of Practical Nervous Diseases

基　　金：四川省卫生厅科研课题(编号:150161)。

摘　　要：从多发性硬化症(MS)与脑白质变化关系的入手,对患者的发病机制、临床表现、影像学检查手段进行分类论述。目前医学界对MS的研究多样化,但无确切的定论证实其与脑白质变化关系深层次的内部关联,本综述论述的发病机制包括血流动力学改变、线粒体假说、血脑屏障破坏、炎症反应假说;MS的临床表现为认知和情感方面的障碍,影像学特征手段有常规MRI、经颅多普勒超声、磁共振扩散张量成像等。本文基于脑白质变化与MS的关系,了解MS的病因和发展,为其治疗和预防提供新的思路和方法。Starting from the relationship between multiple sclerosis(MS)and white matter changes,the pathogenesis,clinical manifestations and imaging methods of patients were classified and discussed.At present,the research on MS in the medical field is diversified,but there is no definitive conclusion to confirm the deep internal relationship between MS and white matter changes.The pathogenesis discussed in this review includes hemodynamic changes,mitochondrial hypothesis,blood-brain barrier destruction,and inflammatory response hypothesis.The clinical manifestations are cognitive and emotional disorders,and the imaging features include conventional MRI,transcranial Doppler ultrasound,magnetic resonance diffusion tensor imaging and other means.Based on the relationship between white matter changes and MS,this paper aims to understand the etiology and development of MS,and provide new ideas and methods for its treatment and prevention.

关 键 词：脑白质变化 多发性硬化症 发病机制 临床表现 影像学 

分 类 号：R744.51[医药卫生—神经病学与精神病学]