胆囊癌神经浸润研究进展  

Research progress of perineural invasion in gallbladder cancer

作　　者：雷建军[1] 张健[1] 张东[1] 张瑞[1] 陈晨[1] 耿智敏[1] Lei Jianjun;Zhang Jian;Zhang Dong;Zhang Rui;Chen Chen;Geng Zhimin(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710061,China)

机构地区：[1]西安交通大学第一附属医院肝胆外科,西安710061

出　　处：《中华消化外科杂志》2023年第7期933-937,共5页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金(62076194);陕西省重点研发计划(2022SF‑410,2022SF‑606)。

摘　　要：神经浸润作为肿瘤的一种特殊转移方式,日益受到重视,其与患者的预后及术后复发转移密切相关。胆囊癌作为胆道系统最常见恶性肿瘤,由于其解剖位置、淋巴回流、血液灌注和神经支配特点,神经浸润也是其预后的独立危险因素。针对胆囊癌的神经浸润特别是机制方面研究甚少,笔者综述近年来胆囊癌神经浸润研究概况和最新进展,主要介绍胆囊癌神经浸润发生机制、发生率、与临床病理特征关系、与预后的关系以及与手术方式及术后辅助治疗关系等。As a special mode of tumor metastasis,perineural invasion has been paid more and more attention.It is closely related to prognosis,recurrence and metastasis of tumor after surgery.As the most common malignancy of the biliary tract,perineural invasion is also an independent prognostic risk factor for gallbladder cancer due to its anatomical location,lymphatic reflux,blood perfusion and innervation.However,there are few studies on perineural invasion in gallbladder cancer,especially on its mechanism.By analyzing the general situation and recent progress of perineural invasion in gallbladder cancer,the authors mainly introduce the perineural invasion mechanism,perineural invasion rate of gallbladder cancer,relationship between perineural invasion and the clinical pathologic characteristic,the correlation with the prognosis,relationship with surgical procedures and postoperative adjuvant therapy.

关 键 词：胆道肿瘤 神经浸润 机制 预后 研究进展 

分 类 号：R735.8[医药卫生—肿瘤]