胆周腺组织功能及其与缺血性胆道病变的关系  

Function of peribiliary glands as well as its relationship with ischemic‑type biliary lesions

作　　者：胡泽同 黄静[1] 毛书奇 吴胜东 童敬澍 陆才德[1] Hu Zetong;Huang Jing;Mao Shuqi;Wu Shengdong;Tong Jingshu;Lu Caide(Department of Hepatopancreatobiliary Surgery,the Affiliated Lihuili Hospital of Ningbo University,Ningbo 315040,Zhejiang Province,China)

机构地区：[1]宁波大学附属李惠利医院肝胆胰外科,宁波315040

出　　处：《中华消化外科杂志》2023年第7期938-942,共5页Chinese Journal of Digestive Surgery

基　　金：宁波市医疗卫生品牌学科(PPXK2018‑03);浙江省基础公益研究计划项目(LY21H030004)。

摘　　要：胆周腺是存在于肝内外胆管周围的一种微小结构,不仅参与维持胆道上皮组织的正常生理功能,在其损伤、修复过程中也发挥重要作用。胆周腺中胆道树干细胞和祖细胞是胆道上皮组织再生、修复的重要细胞来源。胆周腺及胆道周围毛细血管丛是肝移植后缺血性胆道病变发生的关键影响因素。笔者查阅相关文献,结合临床实践,综述胆周腺组织功能及其与缺血性胆道病变的关系。Peribiliary glands(PBG)is a kind of microscopic structure around the intrahepatic bile ducts and extrahepatic bile ducts.PBG not only participates in maintaining the normal physiological function of biliary epithelial tissue,but also plays an important role in its damage and repair process.Biliary tree stem/progenitor cells in PBG are important cell sources of biliary epithelial regeneration and repair.PBG and the surrounding peribiliary vascular plexus are key influencing factors for the occurrence of ischemic-type biliary lesions(ITBL)after liver transplantation.Based on relevant literatures and clinical practice,the authors summarize the function of PBG as well as its relationship with ITBL.

关 键 词：肝疾病 胆道疾病 肝移植 胆周腺 非吻合口狭窄 缺血性胆道病变 低温氧合灌注 

分 类 号：R575.6[医药卫生—消化系统]