血小板聚集、血液黏度及纤维蛋白原检测在急性脑梗死中的价值  

Value of Platelet Aggregation,Blood Viscosity and Fibrinogen Detection in Acute Cerebral Infarction

作　　者：阮甜甜 何圆圆 潘祝艳 RUAN Tiantian;HE Yuanyuan;PAN Zhuyan(Department of Clinical Laboratory,Yancheng Dafeng People's Hospital,Yancheng,Jiangsu Province,224100 China)

机构地区：[1]盐城市大丰人民医院检验科,江苏盐城224100

出　　处：《系统医学》2023年第10期55-58,共4页Systems Medicine

摘　　要：目的 探讨血小板聚集、血液黏度、纤维蛋白原指标用于临床诊断急性脑梗死疾病的价值。方法 抽选2021年1月—2022年12月盐城市大丰人民医院收治的急性脑梗死患者112例作为观察组,选择同期于本院接受体检的健康者112例作为对照组,两组均进行血小板聚集、血液黏度、纤维蛋白原检测,同时对比观察组急性脑梗死患者中急性期与稳定期上述指标的差异,统计对比3项指标单一检测与联合检测用于诊断急性脑梗死的灵敏度与特异性。结果 观察组血小板聚集指标中诱聚剂二磷酸腺苷血小板最大聚集率(90.84±4.21)%、花生四烯酸血小板最大聚集率(74.28±3.99)%、血液高切黏度(6.25±0.38)mPa·s、血液低切黏度(23.94±1.17)mPa·s、纤维蛋白原(2.75±0.43)g/L均高于对照组,差异有统计学意义(t=53.296、32.575、38.818、96.400、14.850,P<0.05)。观察组中,急性期患者血小板聚集、血液黏度、纤维蛋白原高于稳定期患者,差异有统计学意义(P<0.05)。3项指标联合检测的灵敏度高于单一指标检测,差异有统计学意义(P<0.05)。3项指标联合检测的特异性与单一指标检测比较,差异无统计学意义(P>0.05)。结论 临床诊断急性脑梗死疾病可通过血小板聚集、血液黏度、纤维蛋白原3项指标联合检测方式,具有良好的灵敏度,可为疾病诊断提供参考依据。Objective To investigate the value of platelet aggregation,blood viscosity and fibrinogen in clinical diagno‐sis of acute cerebral infarction.Methods 112 patients with acute cerebral infarction admitted to Yancheng Dafeng People's Hospital from January 2021 to December 2022 were selected as the observation group,and 112 healthy people who received physical examination in the hospital at the same time were selected as the control group.Platelet aggregation,blood viscosity,and fibrinogen were detected in both groups.At the same time,the differences of the above indicators between the acute phase and stable phase of patients with acute cerebral infarction in the observation group were compared,the sensitivity and specificity of single and combined detection of three indicators for diagnos‐ing acute cerebral infarction were statistically compared.Results The maximum platelet aggregation rate of adenosine diphosphate(90.84±4.21)%,the maximum platelet aggregation rate of arachidonic acid(74.28±3.99)%,the blood high shear viscosity(6.25±0.38)mPa·s,the blood low shear viscosity(23.94±1.17)mPa·s,and fibrinogen(2.75±0.43)g/L in the observation group were higher than those in the control group,and the difference was statistically significant(t=53.296,32.575,38.818,96.400,14.850,P<0.05).In the observation group,platelet aggregation,blood viscosity,and fibrinogen levels were higher in acute phase patients than in stable phase patients,and the difference was statistically significant(P<0.05).The sensitivity of the combined detection of three indicators was higher than that of a single indi‐cator detection,and the difference was statistically significant(P<0.05).There was no statistically significant differ‐ence in the specificity of the combined detection of three indicators compared to the detection of a single indicator(P>0.05).Conclusion Clinical diagnosis of acute cerebral infarction disease can be through the combined detection of platelet aggregation,blood viscosity and fibrinogen,which has good sensitivit

关 键 词：血小板聚集 血液黏度 纤维蛋白原 检测 急性脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]