动力学拆分在过渡金属催化的不对称(转移)氢化中的应用研究  

Progresses in the Application of Kinetic Resolution in Transition Metal Catalyzed Asymmetric(Transfer) Hydrogenation

作　　者：褚杨杨 韩召斌[2] 丁奎岭[2,3,4] Chu Yangyang;Han Zhaobin;Ding Kuiling(School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032;School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240;Frontiers Science Center for Transformative Molecules,Shanghai Jiao Tong University,Shanghai 200240)

机构地区：[1]上海理工大学材料与化学学院,上海200093 [2]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032 [3]上海交通大学化学化工学院,上海200240 [4]上海交通大学变革性分子前沿科学中心,上海200240

出　　处：《有机化学》2023年第6期1934-1951,共18页Chinese Journal of Organic Chemistry

基　　金：国家重点研发计划(No.2021YFA1500200);国家自然科学基金(No.21872167);上海市优秀学术/技术带头人计划(No.22XD1424800)资助项目。

摘　　要：动力学拆分是一个经典的从外消旋化合物获得光学活性物质的策略,而过渡金属催化的不对称(转移)氢化是高效和高原子经济性地合成手性化合物的方法.将动力学拆分与不对称(转移)氢化相结合,基于已开发的性能优良的过渡金属催化剂,化学家们发展了结构多样的带有不同类型手性中心的不饱和化合物的动力学拆分-不对称(转移)氢化反应,并将其应用于多类手性药物和天然产物的不对称合成中.根据待氢化的不饱和键类型进行分类,综述了该领域所取得的成果,并对后续的发展进行了展望.Kinetic resolution(KR) has long been a popular and classical strategy in organic synthesis to obtain optically active compounds from racemic substrates,and transition metal catalyzed asymmetric(transfer) hydrogenation is a powerful method for the synthesis of chiral compounds with high efficiency and atom economy.Over the years,a large variety of unsaturated compounds bearing different types of chiral centers have been kinetically resolved with great efficiency via asymmetric(transfer) hydrogenation using some well-established chiral transition metal catalysts,and KR has been demonstrated to be a versatile technique in the synthesis of various chiral intermediates for biologically active compounds and natural products.The research progresses in this field are summarized.Moreover,the prospects of further developments are also discussed.

关 键 词：动力学拆分 不对称氢化 不对称转移氢化 过渡金属 

分 类 号：O621.251[理学—有机化学]