巨大垂体腺瘤手术治疗临床效果分析  

Analysis of clinical effect of surgical treatment of giant pituitary adenoma

作　　者：乔建华[1] QIAO Jian-hua(Department of Neurosurgery,Chifeng Municipal Hospital,Chifeng 024000,China)

机构地区：[1]内蒙古赤峰市医院神经外科,024000

出　　处：《中国实用医药》2023年第15期74-77,共4页China Practical Medicine

摘　　要：目的分析巨大垂体腺瘤手术治疗的效果。方法60例巨大垂体腺瘤患者,遵循手术日期的单双号及组间均衡可比原则分为对照组和观察组,各30例。对照组应用显微镜经鼻蝶入路垂体腺瘤切除术,观察组应用神经内镜下经鼻蝶入路垂体腺瘤切除术。对比两组患者围手术期指标、肿瘤切除情况及术后并发症发生情况。结果观察组手术时间(119.56±7.41)min、术后住院时间(12.03±3.51)d均短于对照组的(143.26±8.77)min、(15.68±4.51)d,术中出血量(53.26±10.51)ml少于对照组的(65.56±11.30)ml,差异有统计学意义(P<0.05)。对照组肿瘤次全切7例(23.33%),肿瘤全切23例(76.67%);观察组肿瘤次全切1例(3.33%),肿瘤全切29例(96.97%)。观察组肿瘤全切率高于对照组,差异有统计学意义(P<0.05)。观察组术后并发症发生率为6.67%,明显低于对照组的30.00%,差异有统计学意义(P<0.05)。结论巨大垂体腺瘤患者应用神经内镜下经鼻蝶入路垂体腺瘤切除术治疗效果确切,可以在临床推广使用。Objective To analyze the effect of surgical treatment of giant pituitary adenoma.Methods A total of 60 patients with giant pituitary adenoma were divided into control group and observation group according to the principle of odd-even operation date and balanced comparability between groups,with 30 cases in each group.The control group underwent microscopic transsphenoidal resection of pituitary adenoma,and the observation group underwent neuroendoscopic transsphenoidal resection of pituitary adenoma.The perioperative indexes,tumor resection and postoperative complications were compared between the two groups.Results The operative time and postoperative hospitalization time were(119.56±7.41)min and(12.03±3.51)d in the observation group,which were shorter than those of(143.26±8.77)min and(15.68±4.51)d in the control group;the intraoperative blood loss of(53.26±10.51)ml in the observation group was less than that of(65.56±11.30)ml in the control group;the differences were statistically significant(P<0.05).In the control group,there were 7 cases(23.33%)of subtotal resection and 23 cases(76.67%)of total resection;in the observation group,there were 1 case(3.33%)of subtotal resection and 29 cases(96.97%)of total resection.The total resection rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of postoperative complications in the observation group(6.67%)was significantly lower than that in the control group(30.00%),and the differences were statistically significant(P<0.05).Conclusion The effect of neuroendoscopic transsphenoidal resection of pituitary adenoma in patients with giant pituitary adenoma is accurate and can be widely used in clinic.

关 键 词：巨大垂体腺瘤 手术治疗 神经内镜 显微镜 垂体腺瘤切除术 

分 类 号：R736.4[医药卫生—肿瘤]