Preparation Process of Hydroxypropyl Tetrahydropyrantriol Liposomes  

作　　者：Chun BAI Xin ZHANG Jiayi DING Jing XIONG Tingting LIU Hua JIN Fang YANG Peijue CHEN Lili HE 

机构地区：[1]College of Pharmacy,Southwest Minzu University,Chengdu 610041,China

出　　处：《Medicinal Plant》2023年第4期51-57,共7页药用植物：英文版

基　　金：Supported by Innovation and Entrepreneurship Training Program Project of Southwest Minzu University(S202210656134);Project of Sichuan Department of Science and Technology(2022NSFSC1437);Project of Sichuan Administration of Traditional Chinese Medicine(2021MS121).

摘　　要：[Objectives] To explore the optimal process for preparing hydroxypropyl tetrahydropyrantriol liposomes. [Methods] A refractive index method was used to determine the content of hydroxypropyl tetrahydropyrantriol. Using particle size distribution and encapsulation rate as evaluation indicators, the effects of hydration time, ratio of organic phase to aqueous phase, granulation method, as well as thin film dispersion and reverse evaporation methods on liposomes preparation were investigated, and the optimal preparation method was selected. Single factor experiments were used to screen the drug phospholipid ratio, ultrasound time, and phospholipid cholesterol ratio, and the preparation process was optimized through orthogonal experiments. [Results] The optimal process of preparing hydroxypropyl tetrahydropyrantriol liposomes was as below: 1 : 10 of drug phospholipid ratio, 6 min of ultrasound time, 4 : 1 of phospholipid cholesterol ratio, (60.94%±7.24%) of entrapment efficiency, (86.44±6.08) nm of particle size, (0.195±0.077) of PDI. [Conclusions] The optimal preparation process of hydroxypropyl tetrahydropyrantriol liposomes selected by orthogonal experiment could effectively improve the encapsulation efficiency of hydroxypropyl tetrahydropyranotriol and reduce particle size. Moreover, the method was stable and reliable.

关 键 词：Hydroxypropyl tetrahydropyrantriol Reverse evaporation LIPOSOME Orthogonal design Preparation technology 

分 类 号：R283[医药卫生—中药学]