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作 者:Jianguo LIU Zhe ZHANG Jiechang GAO Jiwen XIE Lin YANG Shenjun HU
机构地区:[1]Department of Traditional Chinese Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430022,China [2]Department of Oncology,The Second Staff Hospital of Wuhan Iron and Steel(Group)Corp.,Wuhan 430085,China
出 处:《Frontiers of Medicine》2011年第1期101-105,共5页医学前沿(英文版)
摘 要:It has been demonstrated thatβ-elemene could protect against carbon tetrachloride(CCl_(4))-induced liver fibrosis in our laboratory work,and the aim of this paper is to reveal the protective mechanisms ofβ-elemene.The hepatic fibrosis experimental model was induced by the hypodermical injection of CCl_(4) in Wistar male rats.β-elemene was intraperitoneally administered into rats for 8 weeks(0.1 mL/100 g bodyweight per day),and plasma endotoxin content was assayed by biochemistry.The serum TNF-αlevel was detected using radioactive immunity.CD14 expression in rat livers was measured by immunohistochemistry and Western blot.The results showed thatβ-elemene can downregulate the levels of plasma endotoxins,serum TNF-α,and hepatic CD14 expression in rats with liver fibrosis.β-elemene plays an important role in downregulating the lipopolysaccharide signal transduction pathway,a significant pathway in hepatic fibrosis development.
关 键 词:liver fibrosis beta-elemene ENDOTOXIN CD14
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