米那普仑与度洛西汀治疗伴有疼痛的老年抑郁症  

Minapulun and duloxetine in the treatment of clinical depression in elderly with pain:A control study

作　　者：穆小梅 牛慧明 王秀梅[1] 白爱萍 王小全[1] 魏长礼 候宁[1] 庞润慧 王军[1] 王都[1] 蔺振林 MU Xiao-mei;NIU Hui-ming;WANG Xiu-mei;BAI Ai-ping;WANG Xiao-quan;WEI Zhang-li;HOU ning;PANG Run-hui;WANG Jun;WANG Du;LIN Zhen-lin(The third People’s Hospital of Tianshui,Tianshui 741000,China)

机构地区：[1]天水市第三人民医院,741000

出　　处：《临床精神医学杂志》2023年第4期303-306,共4页Journal of Clinical Psychiatry

摘　　要：目的:探讨米那普仑与度洛西汀治疗伴有疼痛症状的老年抑郁症的疗效与安全性。方法:将2020年6月至2021年6月天水市第三人民医院门诊符合《国际疾病分类》第10版(ICD-10)诊断标准,伴有疼痛症状的老年抑郁症患者60例随机分为两组(米那普仑组和度洛西汀组)治疗8周,米那普仑组29例,度洛西汀组31例。用数字评估量表(NRS)评定疼痛的严重程度,用汉密尔顿抑郁量表(HAMD)和治疗中出现的症状量表(TESS)评定疗效及不良反应。结果:治疗后2、4、8周末,两组HAMD、NRS评分较治疗前均下降,差异均有统计学意义(P<0.05或P<0.01);治疗2、4、8周末HAMD、NRS评分两组间比较差异均无统计学意义。治疗8周末患者的抑郁症状较治疗前有明显减轻,有效率两组间比较差异无统计学意义。两组患者的药物不良反应基本相似,不良反应发生率差异无统计学意义。结论:米那普仑与度洛西汀治疗伴疼痛症状的老年抑郁患者疗效相当,能有效缓解患者的疼痛和抑郁症状,值得临床推广应用。Objective:To explore the efficacy and safety of minapulun and duloxetine in treatment of depression in old age with pain symptoms.Method:Sixty elderly depressive patients with pain symptoms who met the diagnostic criterion of the International Classification of Diseases(ICD-10)from June 2020 to June 2021 in the third People’s Hospital of Tianshui outpatient service were randomly divided into two groups(minapulun,n=29;duloxetine,n=31),and the course of treatment was 8 weeks.The severity of pain was assessed using the Digital Assessment Scale(NRS),and the efficacy and adverse reactions were assessed using the Hamilton Depression Scale(HAMD)and the Treatment Emergent Symptom Scale(TESS),respectively.Results:The two groups showed score decreases on HAMD and NRS after the treatment,and the score differences from the score before the treatment were significant(P<0.05 or P<0.01).HAMD and NRS score differences between two groups at baseline,the 2nd,4th and 8th weeks after the treatment were not statistically significant.The depressive symptoms in patients were reduced significantly after 8 weeks treatment.The difference of effectiveness rate between the two groups was not statistically significant.The adverse drug reactions were similar in both groups,and the incidence of adverse reactions was not significantly different.Conclusion:Minapulun has the same effect as duloxetine in treatment of pain symptoms in elderly depressed patients,which can effectively relieve the pain and depressive symptoms and is worthy of clinical application.

关 键 词：米那普仑 度洛西汀 疼痛症状 老年抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]