丹参冻干粉联合丁苯酞注射液对急性脑梗死的疗效  

Effect of Danshen freeze-dried powder combined with butylphthalide injection on acute cerebral infarction

作　　者：纪勇顺 郭庆敏 JI Yong-shun;GUO Qing-min(Department of Neurology,the Eighth People's Hospital of Hefei,Hefei 238000,Anhui,China)

机构地区：[1]合肥市第八人民医院神经内科,安徽合肥238000

出　　处：《川北医学院学报》2023年第8期1062-1065,共4页Journal of North Sichuan Medical College

基　　金：安徽省重点研究和开发项目(1704f0804023)。

摘　　要：目的:探究丹参冻干粉联合丁苯酞注射液治疗急性脑梗死(ACI)的效果及其对神经功能、C反应蛋白(CRP)、同型半胱氨酸(Hcy)水平的影响。方法:按治疗方法不同将98例ACI患者分为观察组和对照组,每组各49例。对照组予以常规基础治疗+丁苯酞注射液治疗;观察组在对照组治疗方法基础上增加丹参冻干粉治疗,两组均连续治疗10 d。比较两组临床疗效、治疗后5、10 d的美国国立卫生研究院卒中量表(NIHSS)、简易智力状况检查法(MMSE)评分及血清CRP、Hcy水平。根据NIHSS评分计算临床有效率。结果:治疗后5、10 d,相比于照组,观察组的NIHSS评分均更低;MMSE评分更高(P<0.05)。治疗后10 d,观察组血清CRP、Hcy水平均低于对照组(P<0.05)。观察组临床总有效率(95.92%)高于对照组(83.67%),差异有统计学意义(P<0.05)。结论:丹参冻干粉联合丁苯酞注射液治疗ACI疗效显著,可改善神经功能缺损和认知障碍,降低患者血清CRP、Hcy水平。Objective:To explore the effect of Danshen freeze-dried powder combined with butylphthalide injection on acute cerebral infarction(ACI)and its effect on neurological function,C-reactive protein(CRP)and homocysteine(Hcy)levels.Methods:A total of 98 ACI patients were selected as the research objects.According to the different treatment methods,they were divided into observation group and control group,49 cases in each group.The control group was treated with routine basic treatment and butylphthalide injection.The observation group was treated with Danshen freeze-dried powder on the basis of the control group.Both groups were treated for 10 d.The clinical efficacy,National Institutes of Health Stroke Scale(NIHSS),Mini-Mental State Examination(MMSE)scores and serum CRP and Hcy levels were compared between the two groups at 5 and 10 d after treatment.The clinical response rate were calculated based on NIHSS score.Results:At 5 and 10 d after treatment,NIHSS score was lower and the MMSE score was higher in the observation group than those in the control group(P<0.05).After 10 d after treatment,serum CRP and Hcy in the observation group were lower than those in the control group(P<0.05).The total effective rate in the observation group(95.92%)was higher than that in the control group(83.67%),the difference was statistically significant(P<0.05).Conclusion:Danshen freeze-dried powder combined with butylphthalide injection is effective in the treatment of ACI,which can improve neurological deficits and cognitive impairment,and reduce serum CRP and Hcy levels.

关 键 词：丹参冻干粉 丁苯酞注射液 急性脑梗死 神经功能 C反应蛋白 同型半胱氨酸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]