血清异常凝血酶原联合甲胎蛋白检测在原发性肝癌诊断中的应用  

Application of abnormal serum prothrombin combined with alpha-fetoprotein in the diagnosis of primary liver cancer

作　　者：李静博 苏小红[1] LI Jing-bo;SU Xiao-hong(Department of Laboratory,Liaocheng People's Hospital,Liaocheng 252000,Shandong,China)

机构地区：[1]聊城市人民医院检验科,山东聊城252000

出　　处：《川北医学院学报》2023年第8期1066-1068,1073,共4页Journal of North Sichuan Medical College

基　　金：山东省医学科技项目(2015-01-03-52-1)。

摘　　要：目的:探究血清异常凝血酶原(DCP)联合甲胎蛋白(AFP)检测在原发性肝癌(PLC)诊断中的临床应用价值。方法:选择51例原发性肝癌患者作为PLC组;同时选择同期接受治疗的47例乙型肝炎病毒(HBV)携带者和47例肝硬化(LC)患者分别作为HBV组和LC组;另选择同期在本院进行常规体检的30名健康志愿者作为对照组。各组受检者均采集血液分离血清,对AFP和DCP水平进行测定。以PLC组患者和非PLC组患者(HBV组和LC组)作为因变量,以血清AFP、DCP水平作为自变量进行二元Logistic回归分析。绘制血清AFP、DCP在诊断PLC的受试者工作特征曲线(ROC),分析二者在诊断PLC的诊断效能。结果:各组受检者的血清AFP、DCP水平比较:PLC组>LC组>HBV组>对照组(P<0.05);二元Logistic回归分析结果显示,血清AFP、DCP水平的升高与PLC的发生具有相关性(P<0.05);ROC曲线分析结果显示,血清AFP、DCP在诊断PLC的AUC分别为0.960、0.972,敏感度、特异度分别为86.27%、96.77%和92.16%、93.55%。结论:血清DCP、AFP水平在PLC患者中呈现出高表达,二者在PLC的早期诊断以及病情评价上均具有较高的临床指导意义。Objective:To explore the clinical application value of abnormal prothrombin(DCP)combined with alpha-fetoprotein(AFP)in the diagnosis of primary liver cancer(PLC).Methods:51 patients with PLC were selected as PLC group,47 patients with hepatitis B virus(HBV)and 47 patients with liver cirrhosis(LC)treated in the same period were selected as HBV group and LC group,respectively,and 30 healthy volunteers who underwent routine physical examination in our hospital during the same period were selected as the control group.All groups of subjects collected their serum samples to measure their AFP and DCP levels.With PLC group and non-PLC group(HBV group and LC group)as dependent variables,serum AFP and DCP levels as independent variables,binary Logistic regression analysis was performed.Drew the receiver operating characteristic curve(ROC)of serum AFP and DCP in diagnosing PLC,and analyzed their diagnostic efficiency in diagnosing PLC.Results:Comapared with the levels of serum AFP and DCP in groups:PLC group>LC group>HBV group>control group(P<0.05).Logistic regression analysis showed that the increase of serum AFP and DCP levels was correlated with the occurrence of PLC(P<0.05).ROC curve analysis showed that the AUC of serum AFP and DCP in PLC diagnosis was 0.960 and 0.972,and the sensitivity and specificity were 86.27%,96.77%and 92.16%,93.55%.Conclusion:Serum DCP and AFP levels are highly expressed in PLC patients,and both of them have high clinical guiding value in early diagnosis and disease evaluation of PLC.

关 键 词：异常凝血酶原 甲胎蛋白 原发性肝癌 乙型肝炎病毒 肝硬化 

分 类 号：R735.7[医药卫生—肿瘤]