Research advances of Legionella and Legionnaires’ disease  

作　　者：Xiao-Yong ZHAN Chao-Hui HU Qing-Yi ZHU 

机构地区：[1]Guangzhou Kingmed Center for Clinical Laboratory,Guangzhou 510330,China

出　　处：《Frontiers of Medicine》2010年第2期166-176,共11页医学前沿（英文版）

基　　金：supported by the National Standardization Committee(No.20081021-T-361);the Ministry of Science and Technology of China(No.2008ZX10004-006).

摘　　要：Legionella is a causative agent of legionellosis or Legionnaires’disease.Infection with Legionella spp.is an important cause of community and hospital-acquired pneumonia.Moreover,infection with Legionella is one of the most common causes of severe pneumonia in community settings,and Legionella is isolated in 40%of hospital-acquired pneumonia cases.The clinical features of legionellosis or Legionnaires’disease are not unique,which makes the diagnosis challenging.Macrolides andfluoroquinolones are the most widely used drugs in treatment.Early recognition,treatment and effective measures for prevention and control of the disease are important and required.Although there have been a lot of methods for diagnosis of Legionella infection,they were often time-consuming or complex,not suitable for clinical purposes.This review summarizes available information regarding the microbiology,taxonomy,epidemiology,pathogenesis and diagnosis of Legionnaires’disease,with an emphasis on the laboratory diagnosis of infection with Legionella spp.

关 键 词：LEGIONELLA Legionella pneumophila diagno-sis Legionnaires’disease 

分 类 号：R73[医药卫生—肿瘤]