Functional XPF polymorphisms associated with lung cancersusceptibility in a Chinese population  

作　　者：Dian-Ke YU Chen WU Wen TAN Dong-Xin LIN 

机构地区：[1]State Key Laboratory of Molecular Oncology and Department of Etiology&Carcinogenesis,Cancer Institute&Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100210,China

出　　处：《Frontiers of Medicine》2010年第1期82-89,共8页医学前沿（英文版）

基　　金：supported by the State Key Basic Research Program(No.2004CB518701).

摘　　要：Variation of individuals’DNA repair capacity has been linked to cancer susceptibility.The xeroderma pigmentsum group F(XPF)plays a pivotal role in nucleotide-excision repair(NER)pathway.This study was to examine the functional significance of XPF promoter polymorphisms and their association with lung cancer risk.The function of XPF promoter polymorphisms was tested by a set of biochemical assays,and their effects on lung cancer risk were determined by a case-control analysis of 988 patients with lung cancer and 986 controls.The XPF–673T allele showed a significantly higher transcriptional activity as compared with the–673C allele.The–673TT genotype was associated with a decreased risk of lung cancer compared with the CC genotype(adjusted OR=0.62,95%CI=0.42–0.91;P=0.015)and this effect was more significant among males(adjusted OR=0.55,95%CI=0.35–0.86;P=0.009),elder subjects(adjusted OR=0.51,95%CI=0.30–0.86;P=0.012),and light smokers(adjusted OR=0.35,95%CI=0.14–0.88;P=0.026).Thesefindings suggest that functional polymorphisms influencing DNA repair capa-city may confer susceptibility to lung cancer.

关 键 词：XPF POLYMORPHISM lung cancer 

分 类 号：R73[医药卫生—肿瘤]