躁狂症患者血清NT-3、IGF-1表达水平及其临床意义  

Expressions of serum NT-3 and IGF-1 in patients with mania and their clinical significance

作　　者：李居艳[1] 韩笑乐[1] 李秋英[1] 边云[1] 林晨[1] 陈景旭[1] LI Juyan;HAN Xiaole;LI Qiuying;BIAN Yun;LIN Chen;CHEN Jingxu(Department of Psychosomatic Medicine,Beijing Huilongguan Hospital,Beijing 100096,China)

机构地区：[1]北京回龙观医院心身医学科,北京市100096

出　　处：《广西医学》2023年第12期1418-1421,1426,共5页Guangxi Medical Journal

基　　金：北京市属医院科研培育计划项目(PX2016067)。

摘　　要：目的探讨躁狂症患者血清神经营养素3(NT-3)、胰岛素样生长因子1(IGF-1)表达水平及其临床意义。方法选取87例躁狂症患者作为躁狂症组,同期选取90例健康体检者作为对照组。给予躁狂症组患者常规药物治疗。根据贝克拉范森躁狂量表(BRMS)评分将躁狂症组患者分为轻度躁狂组(n=35)、中度躁狂组(n=28)、重度躁狂组(n=24)。比较对照组研究对象和躁狂症组患者之间,以及不同躁狂程度患者之间治疗前的血清NT-3、IGF-1水平。采用Pearson法分析躁狂症患者治疗前血清NT-3、IGF-1水平与BRMS评分的相关性。比较治疗前后躁狂症患者血清NT-3、IGF-1水平及BRMS评分。采用受试者工作特征曲线分析血清NT-3、IGF-1及二者联合检测对躁狂症的诊断价值。结果治疗前,躁狂症组患者血清NT-3、IGF-1水平较对照组升高,轻度躁狂组、中度躁狂组、重度躁狂组患者血清NT-3、IGF-1水平依次升高(均P<0.05);躁狂症组患者血清NT-3、IGF-1水平与BRMS评分均呈正相关(均P<0.05)。治疗后,躁狂症组患者血清NT-3、IGF-1水平及BRMS评分均较治疗前降低(均P<0.05)。血清NT-3、IGF-1水平单独检测及二者联合检测诊断躁狂症的曲线下面积分别为0.854、0.812、0.887,二者联合检测诊断躁狂症的曲线下面积与血清NT-3、IGF-1水平单独检测诊断的曲线下面积差异无统计学意义(P>0.05)。结论躁狂症患者血清NT-3、IGF-1水平升高,血清NT-3、IGF-1水平与躁狂症患者病情严重程度相关,两者有望成为诊断躁狂症的生物学指标。Objective To explore the expressions of serum neurotrophin 3(NT-3)and insulin-like growth factor 1(IGF-1)in patients with mania and their clinical significance.Methods A total of 87 patients with mania were selected as mania group,and 90 healthy check-up individuals during the same period as control group.The mania group was treated with routine drugs.Patients in the mania group were assigned to mild mania group(n=35),moderate mania group(n=28),or severe mania group(n=24)according to the Bech-Rafaelsen Mania Scale(BRMS)score.The pre-treatment levels of serum NT-3 and IGF-1 were compared between research subjects of the control group and patients of the mania group,and between patients with different degree of mania.The correlation of pre-treatment serum NT-3 and IGF-1 levels with BRMS score in patients with mania was analyzed by using the Pearson method.The serum NT-3 and IGF-1 levels,and BRMS score in patients with mania were compared between before and after treatment.The value of serum NT-3 and IGF-1 and the combined detection of the two for diagnosing mania was analyzed by employing the receiver operating characteristic curve.Results Before treatment,patients in the mania group obtained elevated serum NT-3 and IGF-1 levels as compared with the control group,and the mild,moderate,and severe mania groups exhibited elevated serum NT-3 and IGF-1 levels successively(all P<0.05);in addition,the levels of serum NT-3 and IGF-1 positively correlated with BRMS score in patients of the mania group(all P<0.05).After treatment,the mania group interpreted decline of serum NT-3 and IGF-1 levels,and a decline of BRMS score as compared with before treatment(all P<0.05).The areas under the curve of serum NT-3 and IGF-1 levels of single and combined detection for diagnosing mania were 0.854,0.812,and 0.887,respectively.No statistically significant difference in the area under the curve was found between the combined detection of the two for diagnosing mania and single detection of serum NT-3 and IGF-1 levels for diagnosing mani

关 键 词：躁狂症 神经营养素3 胰岛素样生长因子1 贝克拉范森躁狂量表 诊断价值 

分 类 号：R749.41[医药卫生—神经病学与精神病学]