血清CYFRA21-1、CA125、CA19-9水平联合检测胃癌患者的价值研究  

Study on the value of serum CYFRA21-1,CA125 and CA19-9 levels in detecting gastric cancerpatients

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作  者:谭雪莉 TAN Xuei(Department of Clinical Laboratory Medicine,Xinyang People's Hospital,Henan Xinyang 464000)

机构地区:[1]信阳市人民医院检验科,河南信阳464000

出  处:《医学检验与临床》2023年第6期9-12,共4页Medical Laboratory Science and Clinics

摘  要:目的:分析血清细胞角蛋白19片段抗原21-1(CYFRA21-1)、糖链抗原125(CA125)、糖链抗原19-9(CA19-9)水平联合检测胃癌患者的价值。方法:选取2018年5月-2020年12月我院胃癌患者72例作为试验组,并以1:1配比选取同期72例健康体检者作为对照组。对比两组血清CYFRA21-1、CA125、CA19-9水平、试验组不同分期血清CYFRA21-1、CA125、CA19-9水平、诊断检出率、相关性分析。结果:试验组血清CYFRA21-1、CA125、CA19-9水平高于对照组(P<0.05);TNMⅢ~Ⅳ期者血清CYFRA21-1、CA125、CA19-9水平高于TNMⅠ~Ⅱ期者(P<0.05);CYFRA21-1、CA125、CA19-9、三项联合检测整体比较,特异度、准确度差异有统计学意义,且三项联合检测诊断特异度87.50%(63/72)、准确度88.89%(64/72),高于CYFRA21-159.72%(43/72)、75.00%(54/72),CA12577.78%(56/72)、65.28%(47/72),CA19-980.56%(58/72)、70.83%(51/72)(P<0.05);Pearson分析结果显示,血清CYFRA21-1(r=0.643)、CA125(r=0.712)、CA19-9(r=0.608)水平和胃癌TNM分期呈正相关(P<0.05)。结论:血清CYFRA21-1、CA125、CA19-9在胃癌患者中具有高表达,且不同分期者其水平具有差异,加之联合检测检出率较高,联合检测价值较高。Objective:To analyze the value of serum cytokeratin 19 fragment antigen 2L-1(CYFRA21-1),glycogen antigen 125(CA125)and glycogen antigen 19-9(CA19-9)in the combined detection of gastric cancer patients.Methods:A total of 72 patients with gastric cancer in our hospital from May 2018 to December 2020 were selected as the experimental group,and 72 healthy subjects in the same period were selected as the control group at a ratio of 1:1.The levels of serum CYFRA21-1,CA125 and CA19-9 in the two groups were compared,and the levels of serum CYFRA21-1,CA125 and CA19-9 in the experimental group at different stages,the diagnostic detection rate and the correlation analysis were analyzed.Results:The levels of serum CYFRA21-1,CA125 and CA19-9 in experimental group were higher than those in control group(P<0.05):The levels of CYFRA21-1,CA125 and CA19-9 in patients with TNM Ⅲ~normal stage were higher than those in patients with TNM Ⅰ~Ⅱ(P<0.05).The specificity and accuracy of CYFRA21-1,CA125,CA19-9 and three combined tests were statistically significant,and the diagnostic specificity and accuracy of the three combined tests were 87.50%(63/72)and 88.89%(64/72),which were higher than CYFRA21-159.72%(43/72)and 75.00%(54/72).CA12577.78%(56/72),65.28%(47/72),CA19-980.56%(58/72),70.83%(51/72)(P<0.05);Pearson analysis showed that serum CYFRA21-1(r=0.643),CA125(r=0.712),CA19-9(r=0.608)levels were positively correlated with TNM staging of gastric cancer(P<0.05):Conclusion:Serum CYFRA21-1,CA125 and CA19-9 are highly expressed in patients with gastric cancer,and their levels are different among patients with different stages.In addition,combined detection rate is high and combined detection value is high.

关 键 词:胃癌 胞角蛋白19片段抗原21-1 糖类抗原125 糖链抗原19-9 

分 类 号:R735.2[医药卫生—肿瘤]

 

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