Let-7i:疾病中的关键调控分子和有前景的生物标志物  

Let-7i:A key player and a promising biomarker in diseases

作　　者：侯佳丽 孙璇 HOU Jiali;SUN Xuan(Institute of Reproductive and Stem Cell Engineering,School of Basic Medical Sciences,Central South University,Changsha 410078;National Engineering Research Center of Human Stem Cells,Changsha 410205,China)

机构地区：[1]中南大学基础医学院生殖与干细胞工程研究所,长沙410078 [2]人类干细胞国家工程研究中心,长沙410205

出　　处：《中南大学学报（医学版）》2023年第6期909-919,共11页Journal of Central South University ：Medical Science

基　　金：湖南省自然科学基金(2019JJ50812)。

摘　　要：微RNA(microRNAs,miRNAs)是一种内源性的非编码单链小RNA,通过识别同源序列和干扰转录、翻译或表观遗传过程来调节基因表达。MiRNAs参与多种疾病进程,通过调控靶细胞活性、迁移、侵袭、凋亡、自噬等过程调节机体的生理病理状况。其中,let-7i在多系统中有较高表达,参与肿瘤、心脑血管疾病、纤维化疾病、炎症性疾病、神经退行性疾病等多种疾病进程,并通过不同的信号通路和关键分子在这些疾病中发挥正向或负向调控作用。此外,let-7i可作为多种疾病的早期诊断和预后的生物标志物,成为潜在的治疗靶点。作为生物标志物,let-7i更多的是与其他miRNAs联合用于诊断疾病,评估临床治疗效果或预测预后。MicroRNAs(miRNAs)are endogenous non-coding single-stranded small RNAs that regulate gene expression by recognizing homologous sequences and interfering with transcriptional,translational or epigenetic processes.MiRNAs are involved in a variety of disease processes,and regulate the physiological and pathological status of diseases by modulating target cell activity,migration,invasion,apoptosis,autophagy and other processes.Among them,let-7i is highly expressed in various systems,which participates in the process of tumors,cardiovascular and cerebrovascular diseases,fibrotic diseases,inflammatory diseases,neurodegenerative diseases and other diseases,and plays a positive or negative regulatory role in these diseases through different signal pathways and key molecules.Moreover,it can be used as an early diagnosis and prognostic marker for a variety of diseases and become a potential therapeutic target.As a biomarker,let-7i is frequently tested in combination with other miRNAs to diagnose multiple diseases and evaluate the clinical treatment or prognosis.

关 键 词：let-7i 肿瘤 心脏疾病 纤维化疾病 免疫调节 生物标志物 

分 类 号：R36[医药卫生—病理学]