丁苯酞联合盐酸川芎嗪对脑梗死Toast分型中LAA亚型疗效及血流变学的影响研究  

Effects of Butylphthalide Combined with Tetramethylpyrazine Hydrochloride on the Efficacy and Hemorheology of LAA Subtypes in Toast Classification of Cerebral Infarction

作　　者：李嘉 韩芳 李军[3] LI Jia;HAN Fang;LI Jun(Wanbei Health Vocational College,Suzhou 234000,China;School of Pharmacy,Shandong First Medical University,Jinan 250200,China)

机构地区：[1]皖北卫生职业学院药学系,安徽宿州234000 [2]皖北卫生职业学院,安徽宿州234000 [3]山东第一医科大学

出　　处：《通化师范学院学报》2023年第8期56-62,共7页Journal of Tonghua Normal University

基　　金：山东省自然科学基金项目(ZR2015HL008).

摘　　要：目的:探讨丁苯酞联合盐酸川芎嗪对脑梗死Toast分型中LAA亚型的疗效及血流变学的影响,并查阅文献分析可能原因.方法:选取241例采用丁苯酞联合盐酸川芎嗪治疗的脑梗死患者,依据Toast分型分为对照组(n=123,其中CE亚型61例,SAO亚型42例,SUE亚型14例,SOE亚型6例)和观察组(n=118,均为LAA亚型).此外,对照组和观察组各筛选出需进行血栓弹力图(TEG)检测的患者分别为53例、52例.(1)疗效研究:比较两组患者治疗前后NIHSS、ADL评分值的变化,以及治疗后的总有效率.(2)血流变学研究:比较两组需进行TEG检测的患者纤维蛋白水平、MA值、R值及M值治疗前后的变化.结果:(1)疗效研究:①两组患者治疗前NIHSS和ADL评分无明显差异,治疗后NIHSS评分均降低、ADL评分均增高,但观察组变化幅度更大,组间差异显著;②观察组总有效率高达94.87%,对照组仅有85.37%,组间差异明显.(2)血流变学研究:两组患者治疗前TEG指标无明显差异,治疗后纤维蛋白水平、MA值均下降、R值及K值均升高,组内比较差异明显,但组间比较仍无统计学意义.结论:丁苯酞联合盐酸川芎嗪对脑梗死Toast分型中LAA亚型疗效更好,但血流变学改善并不显著.Objective:To investigate the effect of butylphthalide combined with ligustrazine hydrochloride on LAA subtypes in Toast classification of cerebral infarction and the influence of blood rheology,and to consult the literature to analyze the possible causes.Methods:241 patients with cerebral infarction who were treated with butylphthalide combined with ligustrazine hydrochloride in the Department of Neurology at a tertiary hospital in Suzhou City from December 2019 to June 2022 were selected as the study sub⁃jects.According to Toast classification,241 patients with cerebral infarction were divided into a control group(n=123,including 61 CE subtypes,42 SAO subtypes,14 SUE subtypes,and 6 SOE subtypes)and an observation group(n=118,all LAA subtypes).Among them,53 and 52 patients were selected for thromboelastography(TEG)testing in the control group and the observation group,respectively.Results:(1)Efficacy study:①There was no significant difference in NIHSS and ADL scores between the two groups of patients before treatment.After treatment,both NIHSS scores decreased and ADL scores in⁃creased.However,the observation group had a larger range of changes,with significant differences be⁃tween groups.②The total effective rate of the observation group was as high as 94.07%,while the control group was only 85.37%,with significant differences between the groups;(2)Blood rheology study:there was no significant difference in TEG index between the two groups before treatment,but after treatment,the fibrinogen level and MA value decreased,R value and K value increased,and there was significant dif⁃ference within the group,but there was still no statistical significance between the groups.Conclusion The combination of drugs has a better effect on LAA subtypes,but the improvement of blood rheology is not significant.

关 键 词：丁苯酞 盐酸川芎嗪 TOAST分型 疗效 血流变学 

分 类 号：R743.34[医药卫生—神经病学与精神病学]