Migratory mode transition of astrocyte progenitors in the cerebral cortex: an intrinsic or extrinsic cell process?  

作　　者：Michio Miyajima Hidenori Tabata Kazunori Nakajima 

机构地区：[1]Department of Anatomy,Keio University School of Medicine,Shinjuku-ku,Tokyo,Japan [2]Department of Molecular Neurobiology,Institute for Developmental Research,Aichi Developmental Disability Center,Kasugai,Aichi,Japan

出　　处：《Neural Regeneration Research》2024年第3期471-472,共2页中国神经再生研究（英文版）

基　　金：supported by the Japan Science and Technology Agency-Precursory Research for Embryonic Science and Technology (JPMJPR22SA to MM);Japan Society for the Promotion of Science KA KENHI Grant-in-Aid for Scientific Research(JP21K07309 to HT,JP20H05688 and JP22K19365 to KN);Takeda Science Foundation (to KN);Keio Gijuku Academic Development Funds (to KN);Keio Gijuku Fukuzawa Memorial Fund (to KN)

摘　　要：The cerebral cortex is comprised of properly localized cell types that exert their specific functions.In the developing brain,cells migrate from the germinal region to their functional locations(Silva et al.,2019;Cossart and Garel,2022).For example,neocortical excitatory neurons are generated in the cerebral ventricular and subventricular zones,move to the developing cortical plate via radial migration,and reside in a radial array of six neuronal layers(Oishi and Nakajima,2018).On the other hand,cortical interneurons are mainly generated in ganglionic eminences,migrate tangentially across the cerebral cortex,and reach their final destinations in the cortex(Lim et al.,2018).The failure of neuronal migration leads to defects in cortical layer formation.While the mechanisms of neuronal distribution have been well examined,how astrocytes are diffusely distributed in the cortex is still unclear.Astrocytes are glial cells in the cerebral cortex with several functions,including metabolic support and synapse formation(Abbott et al.,2006;Bosworth and Allen,2017;Allen and Lyons,2018).For example,astrocytes establish synaptic connectivity in the developing brain while they contact numerous synapses and maintain optimal neuronal activity in the adult brain.In the developing brain,astrocytes are primarily generated from radial glia after the neurogenic period.While a certain type of astrocyte called fibrous astrocytes populates the white matter,protoplasmic astrocytes migrate to the cortical plate during neural network formation.

关 键 词：CEREBRAL MIGRATE ABBOTT 

分 类 号：R338[医药卫生—人体生理学]