新诊断SIVD患者认知功能障碍与大脑灰质区大小改变的关系研究  

Study on the Relationship Between Cognitive Dysfunction and Changes in Gray Matter Volume in Patients with New Diagnosed SIVD

作　　者：刘宏[1] 何明方[1] LIU Hong;HE Ming-fang(Department of Cerebrovascular Diseases,Guangyuan Central Hospital,Guangyuan 628000,Sichuan,China)

机构地区：[1]广元市中心医院脑血管病科,四川广元628000

出　　处：《医学信息》2023年第16期104-107,共4页Journal of Medical Information

摘　　要：目的探讨新诊断皮质下缺血性脑血管病(SIVD)认知功能障碍与大脑灰质区大小改变的关系。方法选取我院2018年1月-2021年12月收治的新诊断SIVD患者118例,根据是否认知功能障碍分为认知功能障碍组(54例)和无认知功能障碍组(64例),比较两组人口学资料(性别、年龄及受教育时间)、认知功能评估量表资料(MMSE评分、MoCA评分及CAMCOG-C总分)及影像学检查资料(GDS评分、LI数目、LA分级、灰质总体积、白质总体积及脑脊液容积),分析脑部灰质区体积与认知功能相关量表评分的相关性。结果两组性别、年龄、受教育时间、GDS评分、LI数目、LA分级及脑脊液容积比较,差异无统计学意义(P>0.05);认知功能障碍组MMSE评分、MoCA评分、CAMCOG-C总分、灰质总体积及白质总体积均少于无认知功能障碍组,差异有统计学意义(P<0.05);认知功能障碍组生活质量评分、Stroop评分高于无认知功能障碍组,差异有统计学意义(P<0.05);两组左颞下回、右颞中回、右眶部额上回、左枕中回及右枕中回灰质体积比较,差异有统计学意义(P<0.05);Pearson相关分析显示,合并认知功能障碍患者灰质总体积与MMSE评分、MoCA评分及CAMCOG-C评分呈正相关(P<0.05),脑部灰质总体积与生活质量评分和Stroop评分呈负相关(P<0.05),左颞下回体积与MoCA评分呈正相关(P<0.05),左颞下回体积与Stroop评分呈负相关(P<0.05)。结论伴认知功能障碍新诊断SIVD患者灰质区体积改变可直接影响认知功能。Objective To investigate the relationship between cognitive dysfunction and changes in gray matter volume in patients with new diagnosed subcortical ischemic vascular disease(SIVD).Methods A total of 118 patients with newly diagnosed SIVD admitted to our hospital from January 2018 to December 2021 were selected and divided into cognitive dysfunction group(54 patients)and non-cognitive dysfunction group(64 patients)according to whether they had cognitive dysfunction.The demographic data(gender,age and education time),cognitive function assessment scale data(MMSE score,MoCA score and CAMCOG-C total score)and imaging examination data(GDS score,LI number,LA grade,total gray matter volume,total white matter volume and cerebrospinal fluid volume)were compared between the two groups.The correlation between brain gray matter volume and cognitive function related scale scores was analyzed.Results There was no significant difference in gender,age,education time,GDS score,LI number,LA grade and cerebrospinal fluid volume between the two groups(P>0.05).The MMSE score,MoCA score,CAMCOG-C total score,total gray matter volume and total white matter volume in the cognitive dysfunction group were lower than those in the non-cognitive dysfunction group,and the differences were statistically significant(P<0.05).The quality of life score and Stroop score in the cognitive dysfunction group were higher than those in the non-cognitive dysfunction group,and the differences were statistically significant(P<0.05).There were significant differences in the gray matter volume of left inferior temporal gyrus,right middle temporal gyrus,right orbital superior frontal gyrus,left middle occipital gyrus and right middle occipital gyrus between the two groups(P<0.05).Pearson correlation analysis showed that the total volume of gray matter in patients with cognitive impairment was positively correlated with MMSE score,MoCA score and CAMCOG-C score(P<0.05);the total volume of gray matter in the brain was negatively correlated with quality of life sc

关 键 词：皮质下缺血性脑血管病 认知功能障碍 灰质区 

分 类 号：R743[医药卫生—神经病学与精神病学]