哺乳动物雷帕霉素靶蛋白C1(mTORC1)在非酒精性脂肪性肝病治疗中的作用机制及潜力  

The mechanism and potential of mammalian target of rapamycin complex 1(mTORC1)in treatment for nonalcoholic fatty liver disease

作　　者：郑诗航 杨俊[1] 谭悦[1] 郑长清[1] ZHENG Shihang;YANG Jun;TAN Yue;ZHENG Changqing(Department of Gastroenterology,Shengjing Hospital,China Medical University,Shenyang 110023,China)

机构地区：[1]中国医科大学附属盛京医院消化内科,沈阳110023

出　　处：《临床肝胆病杂志》2023年第8期1946-1951,共6页Journal of Clinical Hepatology

基　　金：辽宁省博士科研启动基金计划项目(2022-BS-140)。

摘　　要：非酒精性脂肪性肝病(NAFLD)已成为全球最常见的慢性肝病,可进展为非酒精性脂肪性肝炎、肝硬化和肝癌。哺乳动物雷帕霉素靶蛋白(mTOR)是一种非典型丝氨酸/苏氨酸蛋白激酶,在细胞生长、凋亡、自噬及代谢等过程中发挥了极为重要的作用。本文阐述mTORC1信号通路在NAFLD发病过程中对细胞代谢和生长分化的作用,进一步提出mTORC1通路对于NAFLD治疗药物的研究价值和潜力。Nonalcoholic fatty liver disease(NAFLD)has become the most common chronic liver disease worldwide and can progress to nonalcoholic steatohepatitis,liver cirrhosis,and liver cancer.Mammalian target of rapamycin(mTOR)is an atypical serine/threonine protein kinase and plays an important role in the processes such as cell growth,apoptosis,autophagy,and metabolism.This article elaborates on the role of the mTOR complex 1(mTORC1)signaling pathway in cell metabolism,growth,and differentiation during in the onset of NAFLD and further proposes the value and potential of the mTORC1 pathway in the research on therapeutic drugs for NAFLD.

关 键 词：TOR丝氨酸-苏氨酸激酶 非酒精性脂肪性肝病 信号传导 药物疗法 

分 类 号：R575[医药卫生—消化系统]