长链非编码小核仁RNA宿主基因(lncRNA SNHG)在肝细胞癌发生发展中的作用  

Research advances in long non-coding small nucleolar RNA host gene in hepatocellular carcinoma

作　　者：李雨韩 郭北辰 周凤 韩涛[1,2] LI Yuhan;GUO Beichen;ZHOU Feng;HAN Tao(Department of Gastroenterology and Hepatology,Clinical Medical College of Tianjin Medical University,Tianjin 300121,China;Department of Gastroenterology and Hepatology,Tianjin Union Medical Center,Nankai University,Tianjin 300121,China)

机构地区：[1]天津医科大学人民临床学院消化(肝病)科,天津300121 [2]南开大学人民医院消化(肝病)科,天津300121

出　　处：《临床肝胆病杂志》2023年第8期1977-1982,共6页Journal of Clinical Hepatology

基　　金：天津市自然科学基金(19JCZDJC36700)。

摘　　要：肝细胞癌(HCC)是原发性肝癌中最常见的类型,也是癌症相关死亡的主要原因之一。尽管目前对HCC的研究逐渐深入,但其潜在的分子机制仍不清楚。近年来研究发现,长链非编码RNA(lncRNA)在HCC的发生和发展中起着重要作用,而长链非编码小核仁RNA宿主基因(lncRNA SNHG)在HCC中异常表达并在肿瘤细胞的增殖、侵袭、转移、血管生成、干细胞特性及耐药性等方面发挥调节作用。本文综述了lncRNA SNHG基因家族在HCC中的发生机制及预后价值,以期为该领域的基础和临床研究提供新思路。Hepatocellular carcinoma(HCC)is the most common type of primary liver cancer and is one of the leading causes of cancer-related deaths.Despite the in-depth research on HCC at present,the underlying molecular mechanisms are still unclear.Recent studies have revealed that long non-coding RNAs(lncRNAs)play an important role in the development and progression of HCC,and long non-coding RNA small nucleolar RNA host genes(lncRNA SNHGs)show abnormal expression in HCC and play regulatory roles in the proliferation,invasion,metastasis,angiogenesis,stemness,and drug resistance of tumor cells.This article reviews the mechanism and prognostic value of the lncRNA SNHG family in HCC,so as to provide new ideas for basic and clinical research in this field.

关 键 词：RNA 长链非编码 癌 肝细胞 作用机制 预后 

分 类 号：R735.7[医药卫生—肿瘤]