环状RNA在肝细胞癌发生发展及诊疗中的作用  

Role of circular RNA in the development,progression,diagnosis,and treatment of hepatocellular carcinoma

作　　者：苗淑莹 杨军[1] 管文燕[1] 张标[1] 何璐 樊智文 MIAO Shuying;YANG Jun;GUAN Wenyan;ZHANG Biao;HE Lu;FAN Zhiwen(Department of Pathology,Nanjing Drum Tower Hospital,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院病理科,南京210008

出　　处：《临床肝胆病杂志》2023年第8期1983-1991,共9页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81700554,82170592)。

摘　　要：肝细胞癌(HCC)作为原发性肝癌最常见的类型,是一种具有侵袭性且致命的恶性肿瘤,其发生发展是一个多基因参与、多步骤、多阶段的过程。环状RNA(circRNA)作为一类内源性非编码RNA,主要通过吸附微小RNA(miRNA)或者RNA结合蛋白(RBP)发挥“海绵作用”,进而调控下游靶基因表达。本文全面介绍了circRNA在HCC信号转导、免疫、代谢、耐药、HBV相关HCC中的作用及意义,及其作为HCC的生物标志物或治疗靶点的潜在价值,为HCC的诊断和治疗提供新思路。As the most common type of primary liver cancer,hepatocellular carcinoma(HCC)is an invasive and fatal malignant tumor,and its development and progression involve multiple genes,steps,and stages.Circular RNA(circRNA),as a class of endogenous non-coding RNAs,mainly acts as a sponge by absorbing microRNA or RNA-binding proteins to regulate the expression of downstream target genes.This article comprehensively introduces the role and significance of circRNA in signal transduction,immunity,metabolism,drug resistance,and hepatitis B virus-related HCC and its potential value as a biomarker or therapeutic target for HCC,so as to provide new ideas for the diagnosis and treatment of HCC.

关 键 词：RNA 环状 癌 肝细胞 诊断 治疗学 

分 类 号：R735.7[医药卫生—肿瘤]